Evidence map›Paper›PMID 42129551›Full record

ArticleNature2026

Lineage and organ signals sequentially build organ intrinsic nervous systems.

I-Uen Yvonne Hsu, Jia Zhao, Yingxin Lin, Yunshan Guo, Qian J Xu, Yuancheng Shao, Ruiqi L Wang, Dominic Yin, Kakali Ghoshal, Rida Mourad and 6 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. The Role of the Nervous System in Lung Disease.Current neurology and neuroscience reports · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

I-Uen Yvonne HsuDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4089-6601
Jia ZhaoDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-9107-8852
Yingxin LinDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4299-7326
Yunshan GuoDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
Qian J XuDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Yuancheng ShaoDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Ruiqi L WangDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-7176-9560
Dominic YinDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-7733-9326
Kakali GhoshalDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN, USA.
Rida MouradDepartment of Pediatrics, Division of Nephrology, Washington University School of Medicine, St Louis, MO, USA.
Ambra PozziDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN, USA.
Carmen M HalabiDepartment of Pediatrics, Division of Nephrology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-4889-8131
Lawrence H YoungDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
Hongyu ZhaoDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1195-9607
Le ZhangDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. le.zhang@yale.edu.ORCID http://orcid.org/0000-0002-4860-831X
Rui B ChangDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. rui.chang@yale.edu.ORCID http://orcid.org/0000-0001-6953-2943

Funding

Understanding the molecular and functional architecture of diverse body-brain pathwaysR01AT012041 · NCCIH · YALE UNIVERSITY · PI CHANG, RUI · 2022 to 2025
$3.0M
Understand the little brain on the heart: a molecular and functional dissection of the intrinsic cardiac nervous systemDP2HL151354 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2019 to 2019
$2.5M
A molecular and functional dissection of the vagal heart-to-brain physiological circuitsR01HL150449 · NHLBI · YALE UNIVERSITY · PI CHANG, RUI · 2020 to 2023
$1.7M
NCCIH NIH HHS R01 AT012041NHLBI NIH HHS DP2 HL151354NHLBI NIH HHS R01 HL150449
6 · The paper itself

Abstract

Organ intrinsic nervous systems (OINSs) are critical components of the body-brain axis and coordinate visceral organ function with systemic physiological control

Indexed as

Cell LineageNervous SystemOrgan SpecificitySignal TransductionAnimalsCell DifferentiationCell MovementCoculture TechniquesExtracellular MatrixHeartIntegrinsIntestinesLungMiceNeural CrestNeurogenesisIntegrins

Identifiers

PMID42129551
PMCPMC13345970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.