Evidence map›Paper›PMID 42129414›Full record

ArticleScientific reports2026

Elevated blood viscosity in thyroid-associated ophthalmopathy and its association with thyroid-stimulating immunoglobulin levels.

Jiyoung Emily Lee, Jungyul Park, Won-Kyung Cho, Ji Sun Paik, Suk-Woo Yang

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Jiyoung Emily LeeDepartment of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jungyul ParkDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Won-Kyung ChoDepartment of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Ji Sun PaikDepartment of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Suk-Woo YangDepartment of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. yswoph@hanmail.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated blood viscosity (BV) is a key factor in vascular diseases; however, its role in thyroid-associated ophthalmopathy (TAO) and its association with autoimmune activity remain unclear. This study examined the relationship between BV, thyroid-stimulating immunoglobulin (TSI) levels, and clinical parameters in TAO. Specifically, we measured the systolic BV (SBV) and diastolic BV (DBV) of 70 patients with TAO and 48 controls using a scanning capillary tube viscometer and examined the correlation between BV and clinical and laboratory markers. Patients with TAO were stratified according to the median BV to assess the differences in TSI and thyroid function markers. Patients with TAO had significantly higher median SBV (p = 0.028) and DBV (p = 0.006) than those in the control group. BV correlated positively with TSI (rho = 0.241, p = 0.044 for SBV; rho = 0.239, p = 0.046 for DBV). T3 showed a weak positive correlation in univariable analysis; however, in multivariable analy`sis, only TSI remained significantly associated with SBV (p = 0.019) and DBV (p = 0.015). TAO was associated with elevated systemic BV, likely related to autoimmune activity and largely explained by hematologic parameters. These findings highlight the interplay between autoimmunity, hematology, and blood rheology.

Indexed as

Blood ViscosityGraves OphthalmopathyAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedAutoimmunityBlood viscosityClinical activity scoreThyroid-associated ophthalmopathyThyroid-stimulating immunoglobulin

Identifiers

PMID42129414
PMCPMC13365443

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