Evidence map›Paper›PMID 42129410›Full record

ArticleScientific reports2026

Distinct clinical course and poor outcomes of small bowel bleeding in acute hematochezia: a nationwide multicenter study.

Yuga Komaki, Naoyuki Tominaga, Atsuo Yamada, Eiji Sadashima, Katsumasa Kobayashi, Atsushi Yamauchi, Jun Omori, Takashi Ikeya, Taiki Aoyama, Yoshinori Sato and 38 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Yuga KomakiDigestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Naoyuki TominagaDepartment of Gastroenterology, Saga-Ken Medical Centre Koseikan, Saga, Japan. tominaga-n@koseikan.jp.
Atsuo YamadaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Eiji SadashimaDepartment of Medical Research Institute, Saga-Ken Medical Centre Koseikan, Saga, Japan.
Katsumasa KobayashiDepartment of Gastroenterology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
Atsushi YamauchiDepartment of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.
Jun OmoriDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Takashi IkeyaDepartment of Gastroenterology, St. Luke's International University, Tokyo, Japan.
Taiki AoyamaDepartment of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.
Yoshinori SatoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, St Marianna University School of Medicine, Kanagawa, Japan.
Takaaki KishinoDepartment of Gastroenterology and Hepatology, Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan.
Naoki IshiiDepartment of Gastroenterology, Tokyo Shinagawa Hospital, Tokyo, Japan.
Tsunaki SawadaDepartment of Endoscopy, Nagoya University Hospital, Aichi, Japan.
Masaki MurataDepartment of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Akinari TakaoDepartment of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Kazuhiro MizukamiDepartment of Gastroenterology, Oita University, Oita, Japan.
Ken KinjoDepartment of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Shunji FujimoriDepartment of Gastroenterology, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.
Takahiro UotaniDepartment of Gastroenterology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan.
Minoru FujitaDivision of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School General Medical Center, Okayama, Japan.
Hiroki SatoDivision of Gastroenterology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Sho SuzukiDepartment of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital, Miyazaki, Japan.
Toshiaki NarasakaDepartment of Gastroenterology, University of Tsukuba, Ibaraki, Japan.
Junnosuke HayasakaDepartment of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
Tomohiro FunabikiDepartment of Emergency Medicine, Fujita Health University Hospital, Aichi, Japan.
Yuzuru KinjoDepartment of Gastroenterology, Naha City Hospital, Okinawa, Japan.
Akira MizukiDepartment of Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Shu KiyotokiDepartment of Gastroenterology, Shuto General Hospital, Yamaguchi, Japan.
Tatsuya MikamiDivision of Endoscopy, Hirosaki University Hospital, Aomori, Japan.
Ryosuke GushimaDepartment of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Hiroyuki FujiiDepartment of Gastroenterology and Hepatology, National Hospital Organization Fukuokahigashi Medical Center, Fukuoka, Japan.
Yuta FuyunoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takuto HikichiDepartment of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
Yosuke ToyaDivision of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan.
Kazuyuki NarimatsuDepartment of Internal Medicine, National Defense Medical College, Saitama, Japan.
Noriaki ManabeDivision of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Okayama, Japan.
Koji NagaikeDepartment of Gastroenterology and Hepatology, Suita Municipal Hospital, Osaka, Japan.
Tetsu KinjoDepartment of Endoscopy, University of the Ryukyu Hospital, Okinawa, Japan.
Yorinobu SumidaDepartment of Gastroenterology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Sadahiro FunakoshiDepartment of Gastroenterological Endoscopy, Fukuoka University Hospital, Fukuoka, Japan.
Kiyonori KobayashiDepartment of Gastroenterology, School of Medicine, Kitasato University, Kanagawa, Japan.
Tamotsu MatsuhashiDepartment of Gastroenterology and Neurology, Akita University Graduate School of Medicine, Akita, Japan.
Kuniko MikiDepartment of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan.
Kazuhiro WatanabeDepartment of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan.
Fumisato SasakiDigestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Shuji KanmuraDigestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Mitsuru KaiseDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Naoyoshi NagataDepartment of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan. nnagata_ncgm@yahoo.co.jp.

Funding

Grants-in-Aid for Research from the National Center for Global Health and Medicine 29-2001JSPS KAKENHI JP17K09365Ministry of Health, Labor, and Welfare (Japan) 19HB1003
6 · The paper itself

Abstract

Although small bowel bleeding is a known cause of acute lower gastrointestinal bleeding (ALGIB), its outcomes compared to colorectal bleeding remain underexplored. This study aimed to identify baseline characteristics and short- and long-term outcomes associated with small bowel bleeding in comparison to colorectal bleeding. This nationwide retrospective cohort study, based on CODE BLUE-J study, involved 10,342 patients hospitalized for ALGIB. Among 195 patients (2.8%) with acute small bowel bleeding, significant associations were observed with laboratory parameters (e.g., low hemoglobin, platelets, and albumin), clinical signs (e.g., tarry stool), and medical history, compared to 6832 patients with colorectal bleeding. Multivariate regression analysis showed no significant difference in 30-day rebleeding or mortality between small bowel and colorectal bleeding. However, small bowel bleeding was associated with higher transfusion volume, lower endoscopic treatment rate, higher rates of interventional radiology and surgery, and longer hospital stay (all p < 0.005). While long-term cumulative rebleeding rates were similar, cumulative mortality was significantly higher in the small bowel bleeding group (p < 0.001). This large-scale endoscopic study revealed differences in several clinical factors at presentation and in short- and long-term outcomes between small bowel and colorectal bleeding. These findings underscore importance of identifying small bowel bleeding in ALGIB.

Indexed as

Gastrointestinal HemorrhageIntestine, SmallAcute DiseaseAgedAged, 80 and overFemaleHumansMaleMiddle AgedRecurrenceRetrospective StudiesTreatment OutcomeAcute lower gastrointestinal bleedingAcute overt small intestinal bleedingCumulative mortality

Identifiers

PMID42129410
PMCPMC13172395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.