ArticleScientific reports2026
Food-sensitized children with juvenile colorectal polyps exhibit a distinct mucosal and fecal microbial signature associated with inflammation.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization.International journal of molecular sciences · 2026Article
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15 authors.
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Abstract
Juvenile colorectal polyps (JCP) are frequent in children and are associated with type 2 inflammation and local IgE synthesis. Our previous work showed that children with JCP in our cohort are sensitized to food allergens. Here, we characterized the bacterial microbiota in fecal samples from food-sensitized children with JCP (FSS) and healthy controls (CS), as well as in JCP tissues and surrounding control tissues (SCT), using 16S rRNA gene sequencing. Although sample richness was comparable across groups, community composition clearly separated fecal from tissue samples and distinguished FSS from CS. ANCOM-BC analysis revealed a distinct microbial profile in FSS, with significant enrichment of genera including Prevotella and Sutterella, and a corresponding reduction in Akkermansia, Veillonella, and several butyrate-producing taxa relative to the CS group. JCP were characterized by enrichment of genera previously associated with inflammatory conditions, including Escherichia, Fusobacterium, and Streptococcus, compared to CS and FSS samples. Notably Akkermansia-depleted in FSS compared to CS-was enriched in JCP when contrasted with FSS, highlighting differences between tissue and fecal microbial profiles across independent cohorts. When compared to the SCT group, JCP samples exhibited higher abundances of Blautia, Phocaeicola, and Dorea. These findings suggest that JCP are associated with a distinct microbial profile across multiple comparisons, whereas FSS is primarily defined by a relative depletion of taxa commonly linked to gut homeostasis. This study provides, to our knowledge, the first comprehensive characterization of the JCP-associated microbiota in food-sensitized pediatric patients, suggesting a potential link between microbial composition and allergic-type inflammation within the polyp microenvironment. Given the limited sample size, particularly for the SCT group, these findings should be considered exploratory.
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