ArticleEye (London, England)2026
Spectral-domain OCT evaluation of anterior sclera and aqueous outflow structures in POAG, ocular hypertension, and healthy eyes.
Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare anterior scleral thickness (AST) and aqueous outflow structure metrics Schlemm's canal area (SCA), trabecular meshwork thickness (TMT), and scleral spur length (SSL) among primary open-angle glaucoma (POAG), ocular hypertension (OHT), and healthy eyes using spectral-domain OCT (SD-OCT), and to evaluate their inter-relationships.
methodsIn this prospective study, we included 126 participants (56 POAG, 24 OHT, 46 controls) from a tertiary glaucoma clinic (January-May 2025). One eye per subject was analysed. SD-OCT (REVO 60, Optopol, Poland) was used to obtain horizontal anterior-segment scans in nasal and temporal quadrants. AST was measured at 0-3 mm from the scleral spur (AST0-AST3); SCA, TMT, and SSL were quantified on exported images using Fiji/ImageJ with pixel-to-micron calibration. Group comparisons employed ANOVA/Kruskal-Wallis with post-hoc tests. Correlations and multiple linear regression assessed determinants of nasal AST0. Inter-observer repeatability was evaluated with ICC.
resultsMean age was 67.9 ± 10.0 (POAG), 62.7 ± 10.4 (OHT), and 62.9 ± 6.6 years (controls). AST0 was significantly lower in POAG and OHT compared with controls in both nasal and temporal quadrants (all p < 0.001). For AST3, temporal values were lower in POAG and OHT compared with controls (p < 0.001), while nasal AST3 showed no significant group difference. SCA and SSL were significantly lower in POAG and OHT compared with controls in both quadrants (all p < 0.001). TMT tended to be lower in patient groups but often did not reach significance. In multivariable analysis, nasal SCA and nasal SSL were independent positive predictors of nasal AST0 (both p < 0.001; model R² = 0.356). Inter-observer ICCs ranged 0.78-0.93 (highest for nasal SCA = 0.93), indicating good repeatability.
conclusionsPOAG and OHT are characterised by a thinner anterior sclera and smaller Schlemm's canal area and scleral spur length compared with controls. The independent association of SCA and SSL with AST supports a biomechanical coupling between the perilimbal sclera and outflow structures. These metrics warrant further longitudinal study for diagnostic/prognostic utility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.