Evidence map›Paper›PMID 42129283›Full record

ArticleScientific reports2026

Spatio-temporal gait signatures across prodromal and early Parkinson's disease in two independent cohorts.

Cinzia Zatti, Clint Hansen, Andrea Rizzardi, Marcello Catania, Robbin Romijnders, Leandro Purin, Maria Pia Pasolini, Andrea Galbiati, Luigi Ferini-Strambi, Inga Liepelt-Scarfone and 10 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Cinzia ZattiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Clint HansenDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.
Andrea RizzardiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Marcello CataniaNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Robbin RomijndersDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.
Leandro PurinNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Maria Pia PasoliniNeurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili of Brescia, Brescia, Italy.
Andrea GalbiatiDepartment of Clinical Neurosciences, Neurology-Sleep Disorders Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Luigi Ferini-StrambiDepartment of Clinical Neurosciences, Neurology-Sleep Disorders Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Inga Liepelt-ScarfoneDepartment for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and German Center of Neurodegenerative Diseases, Tübingen, Germany.
Anna-Katharina von ThalerDepartment of Neurology, Faculty of Medicine, University of Kiel, Kiel, Germany.
Ulrike SünkelDepartment of Psychiatry and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
Bjarne AntonDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.
Maria Cristina RizzettiParkinson's disease Rehabilitation Center, FERB European Fundation Biomedical Research, Trescore Balneario, Italy.
Johanna GeritzDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.
Daniela BergDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Walter MaetzlerDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.
Eva SchaefferDepartment of Neurology, University Hospital Schleswig-Holstein and Kiel University, Kiel, Germany.
Andrea PilottoNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy. pilottoandreae@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gait abnormalities are key features of Parkinson's disease (PD) and might be present in isolated REM Sleep Behavior Disorder (iRBD), a prodromal marker of alpha-synucleinopathy. To assess spatio-temporal gait parameters from prodromal (iRBD) to early/moderate PD stages in normal, fast and dual-task conditions. This prospective multicenter study included two independent cohorts with Polysomnography-confirmed iRBD, drug-naïve PD (naïve-PD), early and moderate treated PD (early-PD, mid-PD), and age-matched healthy controls (HC). Gait was assessed using mobile health technology. A total of 324 participants were enrolled: 194 in the Digital Neurological Assessment (DNA) cohort (23 iRBD, 57 naïve-PD, 49 mid-PD, 65 HC) and 130 in the TPA cohort (28 iRBD, 34 early-PD, 68 HC) composed from TREND, PASS-PD and ABCPD cohorts. In the two independent cohorts, iRBD and early PD (treated and non-treated) showed higher step time compared to HC, especially during dual-task gait. In fast walking, all patient groups had longer step time than HC. Step length was control-like in iRBD and early treated PD, whereas it was lower in both naïve and moderate stages PD in all different task conditions. Temporal gait parameters, especially during dual task walking, are sensitive markers of prodromal PD whereas reduced step length is occurring only in phases when PD diagnosis is already possible. These cross-sectional data need a further validation on ongoing longitudinal studies in prodromal and early stages PD.

Indexed as

GaitParkinson DiseaseProdromal SymptomsAgedCohort StudiesDual-Task TestsFemaleHumansMaleMiddle AgedPolysomnographyProspective StudiesREM Sleep Behavior DisorderGaitMobile health technologyProdromal Parkinson’s diseaseREM sleep behavior disorder

Identifiers

PMID42129283
PMCPMC13365218

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.