ArticleNature communications2026
Structural investigation of QatB and QatC proteins in QatABCD anti-phage defense.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Structural and functional insights into QueC-family protein in QatABCD anti-phage system.Nature communications · 2026Article
- Structural and enzymatic insights into QatD, a dual-function TatD-like nuclease in the QatABCD anti-phage defense system.Nucleic acids research · 2026Article
- Structural basis of QueC-family protein function in qatABCD anti-phage defense.Nature communications · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
QatABCD is a widespread anti-phage defense system in prokaryotes comprising four protein components. QatC, a signature component, is homologous to QueC, an enzyme involved in nucleobase modification during queuosine biosynthesis. QatA and QatD are predicted to function as an ATPase and a nuclease, respectively, while QatB lacks identifiable sequence motifs. Here, we report the structural and functional characterization of QatB and QatC. We determine the structure of QatC bound to the ATP analog AMPPNP and perform structure-guided functional assays. We further find that QatB and QatC form a stable heterodimer and solve the structure of the QatB-QatC complex. In addition to determining the structure of QatB, structural analysis suggests that it may serve as a substrate of QatC, implicating a potential regulatory mechanism. These findings provide structural and functional insights into QatB and QatC, laying a foundation for understanding the molecular mechanism of the QatABCD system in phage defense.
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Registered trials
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