Evidence map›Paper›PMID 42129208›Full record

ArticleNature communications2026

Nanobody-mediated control of long RSH Rel and RelA catalysis by restriction of their conformational landscape.

Katleen Van Nerom, Andres Ainelo, Kyo Coppieters 't Wallant, Ariel Talavera-Perez, Dannele Echemendia-Blanco, Sarah Peeters, Brahim El Khalfaoui Oulali, Hedvig Tamman, Tatsuaki Kurata, Mohammad Roghanian and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Katleen Van NeromCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Brussels, Belgium.
Andres AineloCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Brussels, Belgium.ORCID http://orcid.org/0000-0003-4073-3359
Kyo Coppieters 't WallantBiochemistry and Structural Biology, Université libre de Bruxelles (ULB), Bruxelles, Belgium.ORCID http://orcid.org/0000-0003-2358-999X
Ariel Talavera-PerezCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Brussels, Belgium.ORCID http://orcid.org/0000-0002-1865-5959
Dannele Echemendia-BlancoCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Brussels, Belgium.
Sarah PeetersCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Brussels, Belgium.
Brahim El Khalfaoui OulaliCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Brussels, Belgium.
Hedvig TammanCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Brussels, Belgium.ORCID http://orcid.org/0000-0003-4453-7814
Tatsuaki KurataDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Mohammad RoghanianDepartment of clinical microbiology, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3116-3817
Chloé MartensBiochemistry and Structural Biology, Université libre de Bruxelles (ULB), Bruxelles, Belgium.ORCID http://orcid.org/0000-0002-1617-4238
Els PardonVIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, Brussels, Belgium.ORCID http://orcid.org/0000-0002-2466-0172
Jan SteyaertVIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, Brussels, Belgium.ORCID http://orcid.org/0000-0002-3825-874X
Vasili HauryliukDepartment of Experimental Medical Science, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0003-2389-5057
Abel Garcia-PinoCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Brussels, Belgium. abel.garcia.pino@ulb.be.ORCID http://orcid.org/0000-0002-0634-0300

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 864311
6 · The paper itself

Abstract

Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HD

Indexed as

Escherichia coliEscherichia coli ProteinsLigasesSingle-Domain AntibodiesAllosteric RegulationAnimalsGTP PyrophosphokinaseHydrolysisProtein ConformationRibosomesRNA, TransferTranscription Factor RelAEscherichia coli ProteinsGTP Pyrophosphokinaseguanosine 3',5'-polyphosphate synthetasesLigasesrelA protein, E coliRNA, TransferSingle-Domain AntibodiesTranscription Factor RelA

Identifiers

PMID42129208
PMCPMC13376610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.