ArticleNature communications2026
Discovery and synthesis of flueggeacosines D-F and securingine J.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Securinega alkaloids constitute a structurally diverse class of natural products with intriguing architectures and biological activities. Herein, we report the discovery of four new Securinega alkaloids, flueggeacosines D-F and securingine J, from Flueggea suffruticosa. Flueggeacosines D and E possess dimeric frameworks incorporating a benzoquinolizidine motif derived from allosecurinine backbone. A concise synthetic strategy combining TBADT-catalyzed radical hydroacylation and Mo(CO)
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