Evidence map›Paper›PMID 42129133›Full record

ArticleCell death & disease2026

RNA-binding protein RCAN1.1L modulates ATF2 mRNA stability to promote mitochondrial fission in acute ischemic stroke.

Yanbin Ji, Xiaochun Ma, Liyuan Wang, Fangfei Liu, Yao Tang, Xiaxin Yang, Zexin Zhan, Shuangwu Liu, Juan Zhao, Tan Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yanbin JiDepartment of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.ORCID http://orcid.org/0000-0001-9826-4597
Xiaochun MaDepartment of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Liyuan WangDepartment of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Fangfei LiuDepartment of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yao TangDepartment of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiaxin YangDepartment of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zexin ZhanDepartment of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shuangwu LiuDepartment of Neurology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.ORCID http://orcid.org/0000-0002-9179-1543
Juan ZhaoDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, China.
Tan WangDepartment of Geriatric, Qilu Hospital of Shandong University, Jinan, China.
Fuchen LiuDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital of Shandong University, Jinan, China.
Dexin YuDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Yuguo ChenDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, China. chen919085@sdu.edu.cn.ORCID http://orcid.org/0000-0001-9501-2546
Yan YunDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China. yanyun@email.sdu.edu.cn.ORCID http://orcid.org/0009-0003-2294-7000
Xiulian SunDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital of Shandong University, Jinan, China. xiulians@gmail.com.ORCID http://orcid.org/0000-0002-8206-1346

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82201624
6 · The paper itself

Abstract

Regulator of calcineurin 1 (RCAN1) is an RNA-binding protein with diverse functions, the regulatory mechanisms underlying mitochondrial function in ischemic neuronal injury remain only partially understood. This study identified significantly elevated plasma RCAN1.1 levels in acute ischemic stroke (AIS) patients and demonstrated that mitochondrial translocation of RCAN1.1L ‌within the ischemic penumbra‌ aggravates cerebral infarction ‌by promoting pathological mitochondrial fission and neuronal apoptosis‌. Mechanistically, in AIS cell and mouse models, multi-omics screening identified activating transcription factor 2 (ATF2) mRNA as a critical downstream target of RCAN1.1L. RCAN1.1L binds to the 2915-2935 nucleotide in the 3'-untranslated region (UTR) of ATF2 mRNA, stabilizing its expression and promoting the accumulation of mitochondrial ATF2 (mtATF2) protein. MtATF2, in turn, binds to and upregulates mitochondrial fission 1 (FIS1) protein, thereby enhancing mitochondrial fission and driving intrinsic apoptosis. Notably, the RNA aptamer R1SR13 competitively binds to RCAN1.1L protein with ATF2 mRNA, exerting neuroprotective effects by disrupting the RCAN1.1L-mtATF2-FIS1 axis. These findings identify RCAN1.1L as an upstream regulator of ATF2 mRNA stability-mediated mitochondrial fission and apoptosis in ischemic penumbra neurons and highlight R1SR13 as a promising therapeutic candidate for preserving neuronal mitochondrial integrity.

Indexed as

Activating Transcription Factor 2Intracellular Signaling Peptides and ProteinsIschemic StrokeMitochondrial DynamicsMuscle ProteinsRNA-Binding ProteinsRNA Stability3' Untranslated RegionsAnimalsApoptosisHumansMaleMiceMice, Inbred C57BLMitochondriaNeurons3' Untranslated RegionsActivating Transcription Factor 2Intracellular Signaling Peptides and ProteinsMuscle ProteinsRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID42129133
PMCPMC13342642

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.