Evidence map›Paper›PMID 42129097›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Characterizing pH-Dependent Interactions Between Immunoglobulin and the Neonatal Fc Receptor Using Surface Plasmon Resonance.

Sébastien Menant, Damien Nevoltris, Romain Ollier

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sébastien MenantAC Immune SA, EPFL Innovation Park, Lausanne, Switzerland. sebastien.menant@acimmune.com.
Damien NevoltrisAC Immune SA, EPFL Innovation Park, Lausanne, Switzerland.
Romain OllierAC Immune SA, EPFL Innovation Park, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The internalization of antibody via pinocytosis and its pH-dependent interaction with the neonatal Fc receptor (FcRn) play crucial roles in antibody recycling within circulation. To achieve an optimal half-life, the binding of antibodies to FcRn at acidic pH and their release at physiological pH must be carefully characterized. Here, we describe the use of surface plasmon resonance (SPR) to measure the affinity of human IgG1 antibodies to human FcRn in both acidic (pH 6.0) and physiological (pH 7.4) conditions to evaluate the recycling behavior of therapeutic candidates.

Indexed as

Histocompatibility Antigens Class IImmunoglobulin GReceptors, FcSurface Plasmon ResonanceAntibody AffinityHumansHydrogen-Ion ConcentrationProtein BindingFc receptor, neonatalHistocompatibility Antigens Class IImmunoglobulin GReceptors, FcAffinityAntibody recyclingIgGNeonatal Fc receptorSPR

Identifiers

PMID42129097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.