Evidence map›Paper›PMID 42128971›Full record

ArticleFunctional & integrative genomics2026

Knockout of bsal/cel.2 results in growth retardation, reduced lipid digestion and altered energy metabolism in medaka larvae (oryzias latipes).

Ruipeng Xie, Chenyuan Zhu, Xufang Liang, Ke Lu, Jiaqi Wu

Abstract read
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In one paragraph

Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruipeng XieCollege of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, Wuhan, 430070, China.
Chenyuan ZhuCollege of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, Wuhan, 430070, China.
Xufang LiangCollege of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, Wuhan, 430070, China. xufang_liang@hotmail.com.
Ke LuCollege of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, Wuhan, 430070, China.
Jiaqi WuCollege of Fisheries, Chinese Perch Research Center, Huazhong Agricultural University, Wuhan, 430070, China.

Funding

the National Key Research and Development Program of China 2024YFD2401502
6 · The paper itself

Abstract

To evaluate the significance of bile salt-activated lipase (BSAL) in lipid digestion and metabolism in fish, this study used CRISPR/Cas9 gene editing to generate medaka (Oryzias latipes) bsal mutant lines. Given that the bsal gene comprises three copies (bsal, cel.2, and bsal-like) in the medaka genome, bsal-like variants may lead to functional loss in lipid hydrolysis owing to amino acid residue alterations in the bile salt binding site. Consequently, two types of medaka mutants, bsal

Indexed as

Energy MetabolismFish ProteinsLipaseLipid MetabolismOryziasAnimalsLarvaLipolysisFish ProteinsLipaseBile salt-activated lipaseEnergy metabolismGrowth performanceJapanese medaka (Oryzias latipes)Lipid digestion

Identifiers

PMID42128971

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.