Evidence map›Paper›PMID 42128894›Full record

ArticleNPJ microgravity2026

Optic nerve cerebrospinal fluid drainage via lymphatic vessels in its sheath.

Yang Xu, Wenjing Chen, Yuwei Hu, Huan Wang, Yuan Xie, Ying Cheng, Yuanxi Lin, Xiaoyun Wu, Xiaoxia Ren, Lu Cheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yang Xu *Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenjing Chen *School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yuwei Hu *University of Electronic Science and Technology of China, Chengdu, China.
Huan WangOphthalmology Department, Eastern Hospital, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Yuan XieBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
Ying ChengDepartment of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yuanxi LinUniversity of Shanghai for Science and Technology, Shanghai, China.
Xiaoyun WuCenter for Big Data & Analytics, Shenzhen People's Hospital, Shenzhen, China.
Xiaoxia RenShanxi Eye Hospital, Taiyuan, China. ren_xx1028@126.com.
Lu ChengDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chenglu7412008@163.com.
Ningli WangBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. wningli@vip.163.com.
Ke DuanDepartment of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University, Sichuan Provincial Laboratory of Orthopedic Implant Device R&D and Application Technology Engineering, Luzhou, China. keduan@swmu.edu.cn.
Hui ChenDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 352477354@qq.com.

Funding

National Natural Science Foundation of China 81230029Science and Technology Department of Sichuan Province 2020YFSY0044Space Medical Experiment Project of China Manned Space Program HYZHXMH01003the Fundamental Research Funds for the Central Universities YG2023ZD17the Open Project of the National Facility for Translational Medicine (Shanghai) TMSK02021-103The Youth Science and Technology Project of the Zhangjiagang Municipal Health Commission ZJGQNKJ202510
6 · The paper itself

Abstract

Cerebrospinal fluid (CSF) surrounding the optic nerve is essential for nutrient transport, waste removal, and optic nerve function. Optic disc edema in astronauts during long-duration spaceflight-Spaceflight Associated Neuro-Ocular Syndrome (SANS)-may result from impaired optic nerve CSF drainage, but the drainage pathway remains unclear. Given that the optic nerve sheath is an extension of the cranial meninges, we hypothesized that its CSF drains via lymphatic vessels rather than refluxing into the cranium. We assessed the pressure relationship between intracranial and optic nerve CSF and traced its drainage pathway. Our results show that optic nerve sheath CSF pressure is consistently lower than intracranial pressure, with no reflux observed. Instead, optic nerve CSF drains into deep cervical lymph nodes via lymphatic vessels within the sheath. These findings provide new insights into optic nerve CSF dynamics and may help elucidate SANS pathogenesis.

Identifiers

PMID42128894
PMCPMC13473625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.