Evidence map›Paper›PMID 42128886›Full record

ArticleNature communications2026

CLUES A Comprehensive Workflow for Integrating Geospatial Data in Biomedical Research.

Marcel Jentsch, Elli Polemiti, Paul Renner, Sören Hese, Kerstin Schepanski, Roland Eils, Andre Marquand, Sven Twardziok, Gunter Schumann, environMENTAL consortium

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcel Jentsch *Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.
Elli Polemiti *Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.ORCID 0000-0001-9526-3468
Paul Renner *Department of Earth Observation, Institute of Geography, Friedrich Schiller University Jena, Leutragraben 1, Jena, Germany.ORCID 0009-0002-4472-5700
Sören HeseDepartment of Earth Observation, Institute of Geography, Friedrich Schiller University Jena, Leutragraben 1, Jena, Germany.
Kerstin SchepanskiFreie Universität Berlin, Department of Earth Sciences, Institute of Meteorology, Carl-Heinrich-Becker Weg 6-10, Berlin, Germany.ORCID 0000-0002-1027-6786
Roland EilsBerlin Institute of Health at Charité - Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany.ORCID 0000-0002-0034-4036
Andre MarquandRadboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen, GA, Netherlands.ORCID 0000-0001-5903-203X
Sven TwardziokBerlin Institute of Health at Charité - Universitätsmedizin Berlin, Center of Digital Health, Berlin, Germany. sven.twardziok@bih-charite.de.ORCID 0000-0002-0326-5704
Gunter SchumannGerman Centre for Mental Health (DZPG), Berlin-Potsdam site, Berlin, Germany.
environMENTAL consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental exposures play a critical role in shaping physical and mental health, yet integrating such data into biomedical research remains technically complex and fragmented. The EnvironMENTAL Climate, Urbanicity, Environment and Society (CLUES) framework is an open-source, end-to-end workflow for generating individual-level environmental exposure data. CLUES automates the selection and download of open-access geospatial datasets, standardises spatial and temporal formats, and maps projections, and links resulting environmental variables to individual-level biomedical data, requiring no prior expertise in geospatial data. CLUES covers key environmental domains, including urban and natural space, climate and weather extremes, air pollution, and regional socioeconomic conditions. Designed for extensibility and cross-cohort applicability, it enables multidimensional exposure mapping across global settings and adheres to FAIR (Findability, Accessibility, Interoperability and Reusability) and privacy-compliant data protection principles. In this work, we present the CLUES framework and evaluate its scalability, computational performance, and reproducibility for large-scale biomedical research.

Indexed as

Biomedical ResearchEnvironmental ExposureWorkflowClimateHumansReproducibility of ResultsSoftware

Identifiers

PMID42128886
PMCPMC13172076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.