SynthesisInflammatory bowel diseases2026
The missing evidence: Stricturing Crohn's disease in clinical trials, a systematic review.
Synthesis in Inflammatory bowel diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStricturing Crohn's disease (CD) represents a major cause of morbidity, with limited prospective data addressing response to treatment. We performed a systematic review to evaluate the efficacy of biologic and small-molecule therapies in stricturing CD and to assess the role of imaging modalities in diagnosing and monitoring bowel stenoses.
methodsWe conducted a systematic search of PubMed, Scopus, and Web of Science through August 26, 2025. Prospective studies, including randomized controlled trials and prospective observational cohorts, reporting outcomes in adult patients with stricturing CD treated with biologics or small molecules were included. Risk of bias was assessed using the RoB 2 and ROBINS-I tools.
resultsOf 22 306 records identified, 7 publications corresponding to 10 prospective studies (6 randomized controlled trials, 4 nonrandomized studies) were included. All studies evaluated biologic therapies, predominantly anti-tumor necrosis factor agents; no prospective trials specifically assessed small-molecule therapies in stricturing CD. Due to methodological heterogeneity, a meta-analysis was not appropriate. Across studies, biologic therapy was associated with clinical improvement and, in selected cohorts, reductions in inflammatory activity and need for surgery. Response appeared to vary according to stricture severity, with lower rates in nonpassable lesions. Intestinal ultrasonography and magnetic resonance were investigated in 4 studies, showing reductions in bowel wall thickness.
conclusionsProspective evidence for medical therapy in stricturing CD is limited and restricted to anti-tumor necrosis factor α agents. Imaging plays an important role in characterization and monitoring but lacks a standardized fibrosis assessment. Dedicated phenotype-specific trials and validated imaging biomarkers are needed to optimize management of stricturing CD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.