SynthesisWorld journal of surgery2026
Negative Pressure Wound Therapy Versus Standard Dressings for Preventing Surgical Site Infections Following Abdominal Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Synthesis in World journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
backgroundSurgical site infections (SSIs) are among the most frequent postoperative complications, contributing significantly to patient morbidity, prolonged hospital stays, and increased healthcare costs. Prophylactic negative pressure wound therapy (ciNPWT) has emerged as a potential strategy to reduce SSIs, particularly in abdominal surgery, but its effectiveness remains debated.
objectiveTo evaluate the effectiveness of ciNPWT in reducing SSI rates and other surgical outcomes following abdominal surgery by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).
methodsWe performed a comprehensive meta-analysis of RCTs assessing the use of ciNPWT versus standard wound care in abdominal surgeries including mixed wound contamination classes (e.g., clean-contaminated to contaminated/dirty procedures). The protocol was registered with PROSPERO (https://www.crd.york.ac.uk/prospero/Registration ID: CRD420251005562). Primary outcomes included SSI incidence, while secondary outcomes comprised mortality, hematoma, hospital readmission, reoperation, length of stay, and other incisional complications. Sensitivity analyses and trial sequential analyses were conducted to assess the robustness of findings.
resultsA total of 11 studies involving 2519 patients were included. NPWT significantly reduced the risk of surgical site infection compared to standard dressings (RR = 0.61 (95% CI: 0.44-0.86); p = 0.004). Substantial heterogeneity was present (I
conclusionsciNPWT appears effective in reducing SSIs in abdominal surgery, yet its broader clinical value remains uncertain due to inconsistent benefits across secondary outcomes and unresolved heterogeneity. Future studies should focus on standardizing ciNPWT protocols, identifying high-risk subgroups, and evaluating cost-effectiveness, particularly in resource-limited settings.
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