Evidence map›Paper›PMID 42128668›Full record

ArticleLife science alliance2026

Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma.

Zehui Du, Menghan Li, Brandon H Bergsneider, Andy P Tsai, Kwang Bog Cho, Lily H Kim, John Choi, Gordon Li, Tony Wyss-Coray, Michael Lim and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The MIRO1-BAX Complex Dictates Life and Death at the Mitochondrial Gate.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Zehui DuDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0008-7836-6906
Menghan LiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0007-3117-0570
Brandon H BergsneiderDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7013-8150
Andy P TsaiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Kwang Bog ChoDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Lily H KimDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
John ChoiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Gordon LiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5893-0831
Michael LimDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Xinnan WangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA xinnanw@stanford.edu.ORCID 0000-0002-2640-7082

Funding

Molecular Regulations of Mitochondrial Structure in Neuronal Homeostasis and SurvivalR01NS128040 · NINDS · STANFORD UNIVERSITY · PI XINNAN WANG · 2022 to 2026
$2.2M
A control center for mitochondrial navigation in neuronsR01GM143258 · NIGMS · STANFORD UNIVERSITY · PI WANG, XINNAN · 2021 to 2024
$1.5M
NIGMS NIH HHS R01 GM143258NINDS NIH HHS R01 NS128040NINDS NIH HHS R35 GM16151901
6 · The paper itself

Abstract

Mitochondrial regulators are increasingly recognized for their influence on immune signaling within the tumor microenvironment (TME). In glioma, where immunosuppression limits therapeutic efficacy, we investigate how targeting the mitochondrial protein MIRO1 alters the TME. We combine single-nucleus RNA sequencing of murine gliomas treated in vivo with an MIRO1-binding compound and bulk RNA sequencing of human glioma resections treated with the same compound ex vivo. Cross-species transcriptomic integration reveals an MIRO1-responsive program in the TME. Among shared targets, we identify

Indexed as

Brain NeoplasmsGliomaMacrophagesMitochondrial ProteinsT-LymphocytesTranscriptomeAnimalsCell Line, TumorGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMiceMitochondriaTumor MicroenvironmentMitochondrial Proteins

Identifiers

PMID42128668
PMCPMC13171295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.