ArticleJournal for immunotherapy of cancer2026
Feeder-free generation of functional dendritic cells from human pluripotent stem cells.
Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe scarcity of primary conventional dendritic cells (cDCs) and the limited functionality of monocyte-derived dendritic cells (moDCs) have long hindered mechanistic and translational studies in human dendritic cell (DC) biology and immunotherapy.
methodsWe developed a feeder-free differentiation platform to generate CD1c
resultsThe optimized protocol increased hPSC-cDC yield by more than twofold while reducing cytokine usage. hPSC-cDCs expressed canonical cDC2 markers and aligned transcriptionally with primary cDC2s. These cells exhibited efficient phagocytic activity, robust cytokine secretion in response to poly(I:C) or combined Toll-like receptors agonists, and a partially activated basal state resembling primary CD1c
conclusionsThis feeder-free and DoE-optimized system enables reproducible, large-scale generation of functional hPSC-cDCs that phenotypically and transcriptionally resemble primary cDC2s while exhibiting stronger T-cell priming capacity than moDCs. The platform provides a defined and scalable resource for mechanistic studies, vaccine development, and ex vivo T-cell expansion for cancer immunotherapy.
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