Evidence map›Paper›PMID 42128487›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2026

Exploring the role of cold air in airway hyperresponsiveness and asthma diagnostic testing: a systematic review and meta-analysis.

Nora Fopke Marain, Rani Claus, Marieke Colemont, Steven Ronsmans, Lisa Janssen, Jeroen Vanoirbeek, Dominique Bullens, Lieven Dupont

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nora Fopke MarainKU Leuven, Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery, Leuven, Belgium.
Rani ClausKU Leuven, Department of Public Health and Primary Care, Environment and Health, Leuven, Belgium.
Marieke ColemontKU Leuven, Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery, Leuven, Belgium.
Steven RonsmansKU Leuven, Department of Public Health and Primary Care, Environment and Health, Leuven, Belgium.ORCID https://orcid.org/0000-0002-6767-2691
Lisa JanssenKU Leuven, Department of Public Health and Primary Care, Environment and Health, Leuven, Belgium.
Jeroen VanoirbeekKU Leuven, Department of Public Health and Primary Care, Environment and Health, Leuven, Belgium.ORCID https://orcid.org/0000-0001-5508-3518
Dominique BullensKU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium.
Lieven DupontKU Leuven, Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery, Leuven, Belgium lieven.dupont@uzleuven.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsthma is a heterogeneous disease, making uniform diagnosis challenging, resulting in both under- and overdiagnosis. We conducted a systematic review and meta-analysis to summarise the data on diagnostic accuracy of a cold air bronchial challenge test (CACh) in exercise-induced bronchoconstriction and asthma.

methodsDatabases (PubMed, Embase, Web of Science core collection, Cochrane Library and the Cumulative Index to Nursing and Allied Health Literature

resultsAfter screening and removal of duplicates, 39 studies were included. Aggregate sensitivity and specificity of a FEV

conclusionOur study shows the high sensitivity and specificity and possible clinical implications of a CACh in the diagnosis of asthma. Further research is needed to confirm this.

Indexed as

AsthmaAsthma, Exercise-InducedBronchial HyperreactivityBronchial Provocation TestsBronchoconstrictionCold TemperatureLungAdultFemaleForced Expiratory VolumeHumansMaleMiddle AgedPredictive Value of TestsReproducibility of Results

Identifiers

PMID42128487
PMCPMC13169058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.