ArticleExperimental cell research2026
GSK3β functions as a mechanosensitive regulator that links flow stress to Shh signaling.
Article in Experimental cell research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Primary cilia sense laminar flow through physical deflection, yet how this mechanical cue is translated into signaling regulation remains unclear. Here, we demonstrate that flow-induced ciliary bending promotes the accumulation of GSK3β within cilia, leading to repression of Sonic Hedgehog (Shh) signaling. This response requires the tumor suppressor folliculin (FLCN). Loss of GSK3β results in ligand-independent ciliary accumulation of Smoothened (Smo) and aberrant Shh signaling. Mechanistically, GSK3β phosphorylates Smo at two sites in its C-terminal intracellular domain, and mutations at these sites enhance Smo retention within cilia. Shh stimulation induces inhibitory phosphorylation of GSK3β at T390, thereby relieving its negative regulation of Shh signaling. Together, these findings identify GSK3β as a mechanosensitive regulator that couples flow-induced ciliary bending to Shh pathway activity through control of Smo ciliary localization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.