Evidence map›Paper›PMID 42128066›Full record

ReviewMatrix biology : journal of the International Society for Matrix Biology2026

Glycocalyx and basal lamina in neurological disorders.

Ava Nasrollahi, Peter D Yurchenco, Yao Yao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Matrix biology : journal of the International Society for Matrix Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ava NasrollahiDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC 8, Tampa, FL 33612, USA.
Peter D YurchencoDepartment of Pathology and Laboratory Medicine, Rutgers University-Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Yao YaoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC 8, Tampa, FL 33612, USA. Electronic address: yao7@usf.edu.

Funding

Fibroblast-derived laminin regulates blood-brain barrier integrity and fibroblast biology in hemorrhagic brainR01NS134134 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI Yao Yao · 2023 to 2026
$2.0M
Endothelial laminin in blood brain barrier regulationR01HL146574 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2019 to 2023
$1.9M
The roles of pericyte-derived laminin in neurovascular function and neurodegenerationR01AG065345 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2024 to 2025
$1.2M
Brain extracellular matrix changes during normal aging and in Alzheimer diseaseR21AG091884 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2025 to 2025
$413k
Cell-specific changes of laminin expression in the CNS in Alzheimer’s diseaseR21AG073862 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2021 to 2021
$411k
NHLBI NIH HHS R01 HL146574NIA NIH HHS R01 AG065345NIA NIH HHS R21 AG073862NIA NIH HHS R21 AG091884NINDS NIH HHS R01 NS134134
6 · The paper itself

Abstract

The blood-brain barrier (BBB) is an elegant structure composed of brain endothelial cells, pericytes, astrocyte endfeet, and non-cellular components-the glycocalyx and basal lamina (BL). By actively regulating molecular and cellular exchanges between the blood and the brain, the BBB maintains CNS homeostasis under physiological conditions. BBB disruption drives secondary brain injury after stroke and correlates with stroke outcomes. In Alzheimer's disease (AD), BBB breakdown is an early pathology and plays an important role in cognitive impairment. Previous studies mainly concentrate on how different cellular components of the BBB regulate its integrity in physiological and pathological conditions, leaving the glycocalyx and BL understudied. In this review, we elucidate glycocalyx and BL changes in neurological disorders and discuss the functional significance of these alterations. Specifically, the structure/composition of the glycocalyx and BL as well as the mechanical properties, turnover and assembly of the BL are described first. Next, we summarize how the glycocalyx and BL as well as the major constituents of the BL change in stroke and AD. The functional significance of these alterations is also discussed. Last, we review key questions that need to be answered and future directions in the field.

Indexed as

Alzheimer DiseaseBasement MembraneBlood-Brain BarrierGlycocalyxNervous System DiseasesStrokeAnimalsEndothelial CellsHumansPericytesAlzheimer's diseaseBasal laminaBlood-brain barrierExtracellular matrixGlycocalyxStroke

Identifiers

PMID42128066
PMCPMC13294701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.