Evidence map›Paper›PMID 42127984›Full record

ArticleAnnals of the American Thoracic Society2026

Prognostic Impact of Quantitative CT Disease Extent and Pattern in Fibrotic Hypersensitivity Pneumonitis.

Evans R Fernández Pérez, Stephen M Humphries, David A Lynch, Teng Moua, Sachin Chaudhary, Traci N Adams, Ayodeji Adegunsoye, Mary Beth Scholand, Namita Sood, Brian Vestal

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Article in Annals of the American Thoracic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Evans R Fernández PérezDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO.
Stephen M HumphriesDepartment of Radiology, National Jewish Health, Denver, CO.
David A LynchDepartment of Radiology, National Jewish Health, Denver, CO.
Teng MouaDivision of Pulmonary, Critical Care and Sleep Medicine, Mayo Clinic, Rochester, MN.
Sachin ChaudharyDivision of Pulmonary, Critical Care and Sleep Medicine, University of Arizona, Tucson, AZ.
Traci N AdamsDivision of Pulmonary, Critical Care and Sleep Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Ayodeji AdegunsoyeDivision of Pulmonary, Critical Care and Sleep Medicine, University of Chicago, Chicago, IL.
Mary Beth ScholandDivision of Pulmonary, Critical Care and Sleep Medicine, University of Utah, Salt Lake City, UT.
Namita SoodDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis Medical Center, Sacramento, CA.
Brian VestalDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleQuantitative CT using multiple instance learning (MIL)-usual interstitial pneumonia (UIP) classifier and data-driven textural analysis (DTA) provides objective and reproducible measurements of disease pattern and extent, respectively. However, the understanding of their individual or combined relationships with outcomes in fibrotic hypersensitivity pneumonitis (fHP) remains limited.

objectivesTo determine whether visual CT patterns of fHP or UIP, a MIL-UIP classifier, baseline and changes in DTA over 12-months and DTA at 12 months are associated with progression-free survival (PFS) in fHP.

methodsThe primary cohort included 134 participants with fHP. Associations between CT variables and subsequent lung function change, and PFS were assessed using linear mixed models and Cox hazards models. Results were validated in a combined dataset from three independent populations (N = 216).

resultsVisual patterns of fHP or UIP were not associated with PFS. A baseline MIL-UIP classification and DTA were significantly associated with 24-month PFS. However, the MIL-UIP did not predict PFS after adjusting for DTA fibrosis extent. Over 12 months, a 1-point increase in DTA across and within patients resulted in a significant decline in FVC% and DLCO%. A 12-month change in DTA (HR = 1.07, 95%CI 1.01-1.13) and DTA at 12-months (HR = 1.03, 95%CI 1.01-1.05) were associated with subsequent 12-month PFS. Similar estimates were observed in the validation cohort.

conclusionsIn fHP, the objectively measured extent of lung fibrosis is more prognostic than either a UIP classifier or visual CT patterns of fHP or UIP. Baseline DTA, DTA at 12 months, and its change over 12-months are associated with PFS.

Indexed as

AlveolitisComputer-AssistedExtrinsic AllergicProgression-Free SurvivalRadiographic Image Interpretation

Identifiers

PMID42127984

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.