Evidence map›Paper›PMID 42127913›Full record

ArticleNeuron2026

SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors.

Chiayu Q Chiu, Thomas M Morse, Karima AitOuares, Lauren C Panzera, Paras A Patel, Francesca Nani, Frederic Knoflach, Maria-Clemencia Hernandez, Monika Jadi, Michael J Higley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chiayu Q ChiuDepartment of Neuroscience, Yale University, New Haven, CT, USA.
Thomas M MorseDepartment of Neuroscience, Yale University, New Haven, CT, USA.
Karima AitOuaresDepartment of Neuroscience, Yale University, New Haven, CT, USA.
Lauren C PanzeraDepartment of Neuroscience, Yale University, New Haven, CT, USA.
Paras A PatelDepartment of Neuroscience, Yale University, New Haven, CT, USA.
Francesca NaniRoche Pharmaceutical Research and Early Development, Neuroscience and Rare Diseases (NRD), Roche Innovation Center, Basel, Switzerland.
Frederic KnoflachRoche Pharmaceutical Research and Early Development, Neuroscience and Rare Diseases (NRD), Roche Innovation Center, Basel, Switzerland.
Maria-Clemencia HernandezRoche Pharmaceutical Research and Early Development, Neuroscience and Rare Diseases (NRD), Roche Innovation Center, Basel, Switzerland.
Monika JadiDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Michael J HigleyDepartment of Neuroscience, Yale University, New Haven, CT, USA; Department of Psychiatry, Yale University, New Haven, CT, USA; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. Electronic address: m.higley@yale.edu.

Funding

Bridging cellular and systems neuroscience: synaptic dynamics underlying behaviorDP1EY033975 · NEI · YALE UNIVERSITY · PI HIGLEY, MICHAEL JAMES · 2021 to 2025
$5.9M
Cellular mechanisms of GABAergic inhibition in neocortical dendritesR01MH099045 · NIMH · YALE UNIVERSITY · PI Michael James Higley · 2012 to 2026
$5.7M
Role of GABAergic interneurons in developmental dysregulation of cortical functionR01MH113852 · NIMH · YALE UNIVERSITY · PI CARDIN, JESSICA A, HIGLEY, MICHAEL JAMES · 2017 to 2021
$2.1M
Inhibitory regulation of dendritic calcium signals in the prefrontal cortexK01MH097961 · NIMH · YALE UNIVERSITY · PI CHIU, CHIAYU · 2013 to 2015
$369k
NEI NIH HHS DP1 EY033975NIMH NIH HHS K01 MH097961NIMH NIH HHS R01 MH099045NIMH NIH HHS R01 MH113852
6 · The paper itself

Abstract

Brain activity is highly regulated by GABAergic activity, which can suppress neuronal excitability and synaptic integration. Tonic GABAergic conductances mediated by distinct receptor subtypes can also inhibit neural activity, although the consequences for dendritic calcium signaling are unclear. Here, we use 2-photon calcium imaging both ex vivo and in awake mice to show that α5-GABA

Indexed as

Calcium SignalingDendritesInterneuronsReceptors, GABA-ASomatostatinAction PotentialsAnimalsCalciumMiceMice, TransgenicPyramidal CellsSynaptic TransmissionCalciumReceptors, GABA-ASomatostatincalciumdendriteimaging

Identifiers

PMID42127913
PMCPMC13234774

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.