Evidence map›Paper›PMID 42127892›Full record

ArticleCell2026

Galvanin (TMEM154) is an electric-field sensor for directed cell migration.

Nathan M Belliveau, Matthew J Footer, Amy Platenkamp, Celeste Rodriguez, Heonsu Kim, Christopher K Prinz, Aaron P van Loon, Yubin Lin, Tara E Eustis, Michelle M Chan and 2 more

Abstract read
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In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Nathan M BelliveauDepartment of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA. Electronic address: nathan.belliveau@colorado.edu.
Matthew J FooterDepartment of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Amy PlatenkampDepartment of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Celeste RodriguezDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Heonsu KimDepartment of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Christopher K PrinzDepartment of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Aaron P van LoonDepartment of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Yubin LinDepartment of Electrical and Computer Engineering, Princeton University, Princeton, NJ 08540, USA.
Tara E EustisDepartment of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Michelle M ChanDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Daniel J CohenDepartment of Mechanical and Aerospace Engineering and Omenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ 08540, USA.
Julie A TheriotDepartment of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA. Electronic address: jtheriot@uw.edu.

Funding

A Functional Genomics Approach to Uncover the Mechanisms of Neutrophil Galvanotaxis.R00GM147355 · NIGMS · UNIVERSITY OF COLORADO · PI Nathan M Belliveau · 2025 to 2026
$498k
NIGMS NIH HHS R00 GM147355
6 · The paper itself

Abstract

Directed migration of immune and epithelial cells is critical for rapid responses to tissue injury or infection. Endogenous electric fields, generated by disruption of the transepithelial potential across the skin, are thought to guide cells to wound sites. However, how single cells detect these electrical cues remains unclear. We identified Galvanin (TMEM154), a poorly characterized single-pass transmembrane protein, as required for electric-field-guided migration of rapidly moving cells. Expression of Galvanin is sufficient to confer electric-field-guided migration on otherwise non-responsive epithelial cells. Upon electric-field exposure, Galvanin rapidly relocalizes to the anodal side of cells, and in human neutrophils, relocalization is immediately followed by changes in spatial patterns of cellular protrusion and retraction. These data suggest Galvanin acts as a direct sensor of the electric field, transducing spatial information about a cell's electrical environment to the intracellular migratory apparatus to support directed cell migration.

Indexed as

Cell MovementMembrane ProteinsAnimalsElectricityEpithelial CellsHumansNeutrophilsMembrane Proteinsbiophysicscell biologyCRISPR screendirected cell migrationelectrotaxisfunctional genomicsGalvaningalvanotaxisneutrophilsTMEM154

Identifiers

PMID42127892

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.