Evidence map›Paper›PMID 42127570›Full record

ArticleJACC. Basic to translational science2026

FOXC1 Controls Smooth Muscle Cell Differentiation and Plasticity in Vascular Disease.

Urszula Rykaczewska, Bianca E Suur, Sampath Narayanan, Sofija Sundman, Gaelle Auguste, Quanyi Zhao, Xiang Zhang, Inika Prasad, Åsa Hedman, Mariette Lengquist and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. FOXC1 and Smooth Muscle Cell Plasticity in Human Atherosclerosis.JACC. Basic to translational science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Urszula RykaczewskaDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Bianca E SuurDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Sampath NarayananDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Sofija SundmanDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Gaelle AugusteCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Quanyi ZhaoDivision of Vascular Surgery, Stanford University, California, USA.
Xiang ZhangDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Inika PrasadDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Åsa HedmanDepartment of Medicine, Karolinska Institute, Stockholm, Sweden.
Mariette LengquistDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Malin KronqvistDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Karl SwärdInstitute for Experimental Medical Research, Lund University, Lund, Sweden.
Anton RazuvaevDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Anders MälarstigDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Per ErikssonDepartment of Medicine, Karolinska Institute, Stockholm, Sweden.
Clint MillerCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Thomas QuertermousDivision of Vascular Surgery, Stanford University, California, USA.
Ulf HedinDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Ljubica MaticDepartment of Molecular Medicine and Surgery, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden. Electronic address: Ljubica.Matic@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smooth muscle cell-related transcription factors have been associated with coronary artery disease in large genome-wide association studies, increasing their translational value for therapeutic investigations. Our study shows for the first time that FOXC1 is a major transcriptional regulator in vascular injury and atherosclerotic lesions, causally implicated in the disease. Functionally, our data suggest that FOXC1 modulates smooth muscle cell activation vs quiescence by regulating key pathways involved in cell adhesion, cell cycle progression, and actin cytoskeleton organization. Further investigations should focus on elucidating the mechanistic basis of these regulatory effects and assessing whether this axis could be pharmacologically targeted to promote lesion stability.

Indexed as

atherosclerosisBiKEFOXC1smooth muscle cells

Identifiers

PMID42127570
PMCPMC13197945

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.