Evidence map›Paper›PMID 42127330›Full record

ArticleJournal of proteome research2026

Structural Diversity and Analytical Characterization of Acylhomocarnitines.

Jaclyn Weinberg, William J Crandall, Zachery Ryan Jarrell, Gahyun Lim, Ken Liu, Ho Young Lee, Shakshi Patel, Camilo Anthony Gacasan, Young-Mi Go, Dean P Jones

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jaclyn WeinbergDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-1855-3338
William J CrandallDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-2537-2033
Zachery Ryan JarrellDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Gahyun LimDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Ken LiuDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Ho Young LeeDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Shakshi PatelDepartment of Biochemistry, Department of Medicine, Emory University, Atlanta, Georgia 30322, United States.
Camilo Anthony GacasanDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Emory University, Atlanta, Georgia 30322, United States.
Young-Mi GoDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Dean P JonesDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homocarnitine is a five-carbon analog of carnitine produced in mammals through hydroxylation of the microbiome-derived metabolite δ-valerobetaine. Here, we describe liquid chromatography-mass spectrometry methods for the measurement of fatty acyl-homocarnitines, a previously uncharacterized family of mammalian metabolites. These acyl-homocarnitines are homologs of acyl-carnitines, in which the fatty acid is extended by one carbon. We show that short-chain fatty acyl-CoAs are converted to corresponding acyl-homocarnitines by carnitine acetyltransferase and that these enzyme-generated standards exhibit retention times and ion dissociation patterns identical to acyl-homocarnitines produced by mammalian cells.

Indexed as

CarnitineAcyl Coenzyme AAnimalsCarbon IsotopesCarnitine O-AcetyltransferaseLiquid Chromatography-Mass SpectrometryMiceacylcarnitineAcyl Coenzyme ACarbon IsotopesCarnitineCarnitine O-Acetyltransferaseacylcarnitinecarnitinechromatographyenergy-resolvedfatty acid metabolismHILIChomocarnitineisomermass spectrometryvalerobetaine

Identifiers

PMID42127330
PMCPMC13248012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.