Evidence map›Paper›PMID 42127217›Full record

ArticleScience translational medicine2026

Prime editing of a pathogenic

Lucas Kissling, Francesca Pietrafesa, Matteo Ranucci, Desirée Böck, Nicolas Mathis, Péter István Kulcsár, Eleonora Ioannidi, Lukas Schmidheini, András Tálas, Elina Villiger and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lucas KisslingInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-4989-0695
Francesca PietrafesaInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0009-0007-1458-1677
Matteo RanucciInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-3332-6202
Desirée BöckInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8142-0629
Nicolas MathisInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-4051-8344
Péter István KulcsárInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Eleonora IoannidiInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Lukas SchmidheiniInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-5993-9985
András TálasInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-0851-8333
Elina VilligerInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0009-0002-3454-9045
Hendrik WildnerInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-5075-6269
Xinyue ZhaoInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Konstantinos KompotisInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-4106-4062
Hanns Ulrich ZeilhoferInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-6954-4629
Gerald SchwankInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-0767-2953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Generalized epilepsy with febrile seizures plus (GEFS

Indexed as

AllelesEpilepsy, GeneralizedGene EditingNAV1.1 Voltage-Gated Sodium ChannelSeizuresSeizures, FebrileAnimalsDependovirusDisease Models, AnimalHumansMiceMutationNeuronsPhenotypeNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouse

Identifiers

PMID42127217
PMCPMC7619256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.