Evidence map›Paper›PMID 42127204›Full record

ArticleScience advances2026

Magnetic medical microrobots with memory-capable genetic circuits.

Haotian Chen, Yujun Chen, Yingying Wang, Peng Ning, Yingze Li, Yuantai Sun, Xueyan Wei, Rui Gao, Xing Fan, Feng Tao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Haotian ChenState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.ORCID 0009-0000-9758-4054
Yujun ChenState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.ORCID 0000-0003-3112-0593
Yingying WangState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Peng NingState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Yingze LiState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Yuantai SunState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Xueyan WeiState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Rui GaoState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Xing FanState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Feng TaoState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Zihan GuoState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Weicheng GuState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.
Zhenguang LiState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.ORCID 0009-0008-0483-7322
Xinjian FanSchool of Mechanical and Electric Engineering, Soochow University, Suzhou 215123 China.ORCID 0000-0002-8854-1287
Zhen YinState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.ORCID 0000-0003-4068-5422
Yu ChengState Key Laboratory of Autonomous Intelligent Unmanned Systems, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Collaborative Innovation Center for Brain Science, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434 China.ORCID 0000-0002-9030-2023

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autonomous microrobots can reach hard-to-access regions in the human body for minimally invasive therapy. However, their microscale size limits the integration of on-board memory, making their operation dependent on external controls. Here, we develop a magnetic probiotic microrobot integrated with memory-capable genetic circuit to execute autonomous antitumor treatment. Through a one-time magnetic hyperthermia trigger, the biological thermal sensor in the microrobot perceives temperature change and activates the memory module Bxb1-ssrA-

Indexed as

Gene Regulatory NetworksMagneticsNeoplasmsRoboticsAnimalsAutonomous RobotsHumansHyperthermia, InducedMiceTumor Microenvironment

Identifiers

PMID42127204
PMCPMC13170677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.