Evidence map›Paper›PMID 42127201›Full record

ArticleScience advances2026

Beyond seizure control: Identifying deficits in cognitive networks in absence epilepsy.

Gil Vantomme, Gabrielle Devienne, Jacob M Hull, John R Huguenard

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Gil VantommeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7441-0737
Gabrielle DevienneDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2204-8043
Jacob M HullDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1812-0214
John R HuguenardDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6950-1191

Funding

Inhibitory Controls of Thalamic NeuronsR01NS034774 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 1996 to 2021
$5.5M
Inhibitory Controls in the Thalamic Reticular NucleusR37NS034774 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 2004 to 2010
$2.5M
Tracking pre-seizure dynamics to predict and control seizuresR01NS117150 · NINDS · STANFORD UNIVERSITY · PI GANGULI, SURYA, HUGUENARD, JOHN R · 2020 to 2024
$2.1M
NINDS NIH HHS R01 NS034774NINDS NIH HHS R01 NS117150NINDS NIH HHS R37 NS034774
6 · The paper itself

Abstract

Cognitive impairments are common in absence epilepsy, yet the neural basis of these deficits remains largely unknown. Communication between the thalamic reuniens nucleus and the prefrontal cortex is critical for flexible behavior. Here, we identify a disruption of this pathway in mice with absence epilepsy. This dysfunction leads to impaired cognitive flexibility and altered cortical inhibition, linking seizure-related thalamic activity to prefrontal network imbalance. Notably, targeted stimulation of the thalamic-prefrontal pathway alleviates both seizure occurrence and cognitive deficits. These findings reveal a shared circuit mechanism underlying epileptic and cognitive symptoms, pointing to new strategies for intervention.

Indexed as

CognitionCognitive DysfunctionEpilepsy, AbsenceNerve NetSeizuresAnimalsDisease Models, AnimalMaleMicePrefrontal Cortex

Identifiers

PMID42127201
PMCPMC13170670

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.