Evidence map›Paper›PMID 42127180›Full record

ArticleScience advances2026

PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function.

Jia Tong, Yang Liu, Wanliu Wu, Qianqian Wang, Huifang Yang, Junyao Li, Ziyan Gao, Weizhen Liu, Jie Liu, Paul Chazot and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jia TongThe Second Affiliated Hospital of Xinxiang Medical University, He'nan Key Laboratory of Biological Psychiatry (Xinxiang Medical University), Xinxiang, He'nan, 453002, China.ORCID 0000-0003-1835-7385
Yang LiuInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, He'nan 453003, China.
Wanliu WuInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, He'nan 453003, China.
Qianqian WangInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, He'nan 453003, China.
Huifang YangInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, He'nan 453003, China.
Junyao LiInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, He'nan 453003, China.
Ziyan GaoInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, He'nan 453003, China.
Weizhen LiuInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, He'nan 453003, China.ORCID 0009-0005-1815-4854
Jie LiuHe'nan Medical Key Laboratory for Research of Trauma and Orthopedics, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, He'nan 453003, China.ORCID 0009-0001-3102-991X
Paul ChazotDepartment of Biosciences, Wolfson Research Institute for Health and Wellbeing, Durham University, Durham, UK.
Liaoxun LuSchool of Medical Technology, He'nan Medical University, Xinxiang, He'nan 453003, China.
Yinming LiangSchool of Medical Technology, He'nan Medical University, Xinxiang, He'nan 453003, China.ORCID 0000-0001-9174-4037
Chengbiao LuThe Second Affiliated Hospital of Xinxiang Medical University, He'nan Key Laboratory of Biological Psychiatry (Xinxiang Medical University), Xinxiang, He'nan, 453002, China.ORCID 0000-0001-9074-4430

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Palmitoylation is a reversible lipid modification, regulating protein localization and signaling in neurons. Growth-associated protein 43 (GAP43) requires palmitoylation for axonal development and synaptic plasticity; however, its depalmitoylase and regulation in neural circuits remain unknown. We investigated whether palmitoyl-protein thioesterase 1 (PPT1) is the principal depalmitoylase for GAP43 and examined how disrupted PPT1-GAP43 signaling affects neuronal morphology and circuit function. Using biochemical assays, structural modeling, CRISPR-Cas9-generated GAP43 point mutation mice (GAP43-PM), PPT1-knockout mice (PPT1-KO), electrophysiology, and behavior, we demonstrated that PPT1 interacts with GAP43 at Cys

Indexed as

CognitionGAP-43 ProteinNeuronsThiolester HydrolasesAnimalsHippocampusHumansLipoylationMiceMice, KnockoutNeuronal PlasticityGAP-43 Proteinpalmitoyl-protein thioesteraseThiolester Hydrolases

Identifiers

PMID42127180
PMCPMC13170661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.