ArticlePloS one2026
Cost-effectiveness analysis of mepolizumab among patients with severe asthma from the Chinese societal perspective.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03562195 (A Randomized, Double Blind, Parallel Group Study of the Efficacy and Safety of Mepolizumab as Adjunctive Therapy in Patients With Severe Asthma With Eosinophilic Inflammation), which is not on this map. Not yet cited in PubMed.
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A Randomized, Double Blind, Parallel Group Study of the Efficacy and Safety of Mepolizumab as Adjunctive Therapy in Patients With Severe Asthma With Eosinophilic Inflammation
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5 authors.
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Abstract
backgroundPatients with severe asthma, particularly those with an eosinophilic phenotype, face a limited array of treatment options. The Mepolizumab Efficacy in Patients with Severe Asthma (MENSA) trial (clinicaltrials.gov NCT03562195) has underscored the potential therapeutic benefits of mepolizumab as an adjunctive treatment for this patient group. However, the high cost of mepolizumab therapy presents significant economic challenges that may impede its widespread adoption in China. This study aims to assess the cost-effectiveness of mepolizumab from a societal perspective within the Chinese population suffering from severe asthma.
methodsA Markov model spanning a lifetime horizon and employing a 2-week cycle was constructed. The model incorporated clinically significant exacerbations (CSEs) rates from the MENSA trial, along with asthma mortality rates, costs, and health state utilities, sourced from a broad spectrum of literature and national databases. Both costs and effectiveness outcomes were discounted annually at 5%. Incremental cost-effectiveness ratios (ICERs) were calculated as the primary model output and compared to a willingness-to-pay (WTP) threshold range of $15,217 to $38,042 per quality-adjusted life-years (QALY). The model's robustness was evaluated through sensitivity analyses.
resultsThe base-case analysis indicated an ICER of $848.79 per QALY for mepolizumab, fall below the lower limit of the predefined WTP threshold. Subgroup analyses confirmed this finding across different subpopulations. Deterministic sensitivity analyses showed that mepolizumab's ICER remained below the lower limit of the predefined WTP threshold even under significant parameter variations. Probabilistic sensitivity analyses further demonstrated mepolizumab's cost-effectiveness advantage over placebo.
conclusionOur study concluded that mepolizumab is a cost-effectiveness treatment option for severe asthma in China, applicable across various patient subgroups. This finding is crucial for healthcare decision-makers in China, where balancing cost and health outcomes is essential due to limited resources.
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