Evidence map›Paper›PMID 42126964›Full record

ArticleeLife2026

Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of

David Jones, Hugo Belda, Malgorzata Broncel, Gwendolin Fuchs, David Anaguano, Stephanie D Nofal, Moritz Treeck

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Febrile temperature enhancesbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David JonesSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0002-4789-203X
Hugo BeldaSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0001-8628-9455
Malgorzata BroncelSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0003-2991-3500
Gwendolin FuchsSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0001-9294-6984
David AnaguanoThe Cell Biology of Host-Pathogen Interactions Lab, Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.ORCID https://orcid.org/0000-0001-7384-8377
Stephanie D NofalSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0003-1415-3369
Moritz TreeckSignalling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0002-9727-6657

Funding

European Commission 10144428Fundação para a Ciência e a Tecnologia 2023.06167.CEECINDFundação para a Ciência e a Tecnologia 2024.02695.BDThe Francis Crick Institute CR2023/030/2132Wellcome Trust 10.35802/225686Wellcome Trust CC0199Wellcome Trust CC2132
6 · The paper itself

Abstract

Fever is a hallmark of malaria. Several studies have linked febrile temperatures to reduced parasite viability, but also to increased cytoadhesion, a key driver of pathology. However, different mechanisms have been proposed to cause changes in cytoadhesion and parasite sensitivity to heat. Here, we demonstrate that exposure of

Indexed as

Cell AdhesionErythrocytesHeat-Shock ResponseMembrane ProteinsPlasmodium falciparumProtozoan ProteinsHumansMalaria, FalciparumProtein Transporterythrocyte membrane protein 1, Plasmodium falciparumMembrane ProteinsProtozoan Proteinscell biologyfeverinfectious diseasemalariamicrobiologypathogenesisP. falciparumPlasmodium falciparumprotein trafficking

Identifiers

PMID42126964
PMCPMC13171106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.