Evidence map›Paper›PMID 42126950›Full record

ArticleThe Kaohsiung journal of medical sciences2026

Joint and Independent Associations of Dietary Antioxidant Intakes With Advanced Stages in Older Patients With Cardiovascular-Kidney-Metabolic Syndrome.

Fu-Shan Qiu, Jian-Chao Qi, Mei-Zhu Lin, Jun-Hua Ke

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Article in The Kaohsiung journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Fu-Shan QiuDepartment of Geriatric Rehabilitaton, Rehabiliation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Jian-Chao QiFuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
Mei-Zhu LinDepartment of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Jun-Hua KeDepartment of Geriatric Rehabilitaton, Rehabiliation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.ORCID https://orcid.org/0009-0008-9678-5573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explored the association between the composite dietary antioxidant index (CDAI) and cardiovascular-kidney-metabolic (CKM) progression in an older population. Using data from NHANES 2001-2020, we analyzed 4974 adults aged ≥ 60 years with CKM syndrome. The CDAI was calculated from the intake of six dietary antioxidants. Associations between the CDAI and its components and advanced CKM syndrome (Stages 3-4) were assessed using multivariable logistic regression, restricted cubic splines, piecewise logistic regression, and weighted quantile sum (WQS) regression. Participants in the highest CDAI quartile had lower odds of advanced CKM syndrome than those in the lowest quartile (OR = 0.728, 95% CI: 0.594-0.893). Restricted cubic spline analysis showed an L-shaped association between CDAI and odds of advanced CKM syndrome, with an inflection point at 5.857; the inverse association was evident below this threshold and plateaued above it. Furthermore, the WQS regression model identified a protective combined effect of the six dietary antioxidants against advanced CKM syndrome, with vitamin A and vitamin C contributing the largest weights. Higher CDAI levels were associated with a lower risk of advanced CKM syndrome in older adults, with vitamins A and C emerging as the most influential components.

Indexed as

cardiovascular‐kidney‐metabolic syndromecomposite dietary antioxidant indexNHANESolder adultsweighted quantile sum regression

Identifiers

PMID42126950
PMCPMC13399601

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.