Evidence map›Paper›PMID 42126917›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

SCD1 Regulates Osteoclast Differentiation by Modulating Arachidonic Acid Metabolism and Mitochondrial Homeostasis.

Yihao Zhao, Xiaoan Wei, Haihao Wu, Chengjun Yao, Zeyu Zheng, Weishao Chen, Zhenhua Feng, Bao Huang, Zimin Cai, Qize Xue and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yihao ZhaoDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaoan WeiDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Haihao WuDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chengjun YaoDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zeyu ZhengDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Weishao ChenSchool of Medicine, Hangzhou City University, Hangzhou, China.
Zhenhua FengDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Bao HuangDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zimin CaiDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Qize XueDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jian ChenDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Fengdong ZhaoDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Junhui LiuDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Funding

MOST | | Medical Science and Technology Project of Zhejiang Province () 2023564481MOST | National Natural Science Foundation of China (NSFC) 82302732MOST | National Natural Science Foundation of China (NSFC) 82402873MOST | National Natural Science Foundation of China (NSFC) 82472472Zhejiang Provincial Natural Science Foundation of China LZ23H060002
6 · The paper itself

Abstract

Bone homeostasis is maintained by a dynamic balance between bone formation and resorption. Here, we link lipid metabolism to osteoclast differentiation by identifying stearoyl-CoA desaturase-1 (SCD1) as a key regulatory factor. Notably, SCD1 expression was significantly upregulated during osteoclast differentiation, and knockdown of SCD1 or inhibiting its activity with A939572 significantly impaired osteoclast formation. Integrating RNA sequencing and metabolomics, we revealed that SCD1 inhibition altered arachidonic acid metabolism and influenced mitochondrial homeostasis. Mechanistically, A939572 upregulated COX1 and HPGDS expression, leading to the accumulation of Prostaglandin D2 (PGD2), which in turn suppressed osteoclast differentiation. Finally, we engineered a biomimetic nanovesicle (POCM-NP@A939572) coated with preosteoclast membrane for targeted delivery. In vivo, POCM-NP@A939572 exhibited superior efficacy in preventing bone loss compared to A939572 alone. Collectively, this study demonstrates the SCD1-COX1-PGD2 axis as a therapeutic target and demonstrates the value of targeted nanomedicine in managing bone diseases.

Indexed as

Arachidonic AcidsBone ResorptionEnzyme InhibitorsOsteoclastsStearoyl-CoA DesaturaseAnimalsCell DifferentiationCyclooxygenase 1FemaleMaleMAP Kinase Signaling SystemMembrane ProteinsMiceMice, Inbred C57BLMitochondriaNanoparticle Drug Delivery SystemArachidonic AcidsCyclooxygenase 1Enzyme InhibitorsMembrane ProteinsNanoparticle Drug Delivery SystemProstaglandin D2Ptgs1 protein, mouseScd1 protein, mouseStearoyl-CoA DesaturaseA939572arachidonic acid metabolismnanoparticlesosteoclastosteoporosisSCD1

Identifiers

PMID42126917
PMCPMC13170736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.