ArticleJournal of applied research in intellectual disabilities : JARID2026
Immediate and Underlying Causes of Death and Survival Rates in Aging Adults With Down Syndrome.
Article in Journal of applied research in intellectual disabilities : JARID, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo describe immediate and underlying causes of mortality (using ICD-10 codes) and survival rates of aging adults with Down syndrome (Ds).
methodThis secondary analysis used the Healthy Aging and Intellectual Disabilities cohort. Adults with Ds (n = 149, ≥ 50 years at baseline) were matched 1:1 to adults with intellectual disabilities without Ds on age, sex and level of intellectual disability. Follow-up was ~10 years post-baseline, or at death.
resultsThe most common immediate and underlying causes of death in adults with Ds were respiratory diseases/infections, followed by cardiovascular disease and neuropsychiatric conditions. Unknown causes accounted for 29%-50% of deaths. Adults with Ds had higher mortality than matched comparators (HR = 5.05, 95% CI 3.10-7.47), increasing significantly with each year of age (HR = 1.08/year, 95% CI 1.04-1.11).
conclusionRespiratory diseases, cardiovascular and neuropsychiatric conditions are important contributors to mortality in older adults with Ds, but large numbers of missing causes warrant cautious interpretation.
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