Evidence map›Paper›PMID 42126785›Full record

ArticleUpdates in surgery2026

Sustained virological response improved survival outcomes after curative resection in patients with hepatitis C virus-related hepatocellular carcinoma in the era of direct‑acting antiviral therapy.

Yi-Hao Yen, Chee-Chien Yong, Chao-Hung Hung, Chien-Hung Chen, Sheng-Nan Lu, Tsung-Hui Hu, Jing-Houng Wang, Yueh-Wei Liu, Wei-Feng Li, Chih-Chi Wang and 1 more

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Article in Updates in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yi-Hao Yen *Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan. cassellyen@yahoo.com.tw.ORCID http://orcid.org/0000-0001-6251-7230
Chee-Chien YongLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan.
Chao-Hung HungDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Chien-Hung ChenDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Sheng-Nan LuDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Tsung-Hui HuDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Jing-Houng WangDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Yueh-Wei LiuLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan.
Wei-Feng LiLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan.
Chih-Chi Wang *Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan. ufel4996@ms26.hinet.net.
Chih-Yun LinBiostatistics Center of Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Funding

Kaohsiung Chang Gung Memorial Hospital CMRPG8L0181Kaohsiung Chang Gung Memorial Hospital CMRPG8L0182Kaohsiung Chang Gung Memorial Hospital CORPG8N0271
6 · The paper itself

Abstract

BACKGROUND AND

aimThe impact of sustained virological response (SVR) on outcomes of patients with hepatocellular carcinoma (HCC) undergoing liver resection (LR) was assessed.

methodsThis retrospective cohort study included 344 patients with hepatitis C virus (HCV)-related HCC who underwent LR. Patients were divided into three groups: preoperatively achieving SVR (pre-SVR); postoperatively achieving SVR (post-SVR); and not achieving SVR (non-SVR).

results145 patients received direct-acting antivirals, 76 received interferon-based therapy, and 123 were untreated. 95 patients were pre-SVR, 87 were post-SVR, and 162 were non-SVR, including untreated patients. Five-year overall survival was 83% in the pre-SVR group, 92% in the post-SVR group, and 50% in the non-SVR group (p < 0.001). Pre-SVR (adjusted HR (aHR) 0.35; 95% CI 0.19-0.62; p < 0.001) and post-SVR (aHR 0.18; 95% CI 0.09-0.36; p < 0.001) were independent predictors of mortality. Five-year recurrence-free survival was 75% in the pre-SVR group, 55% in the post-SVR group, and 45% in the non-SVR group (p < 0.001). Pre-SVR (aHR 0.45; 95% CI 0.28-0.73; p = 0.001) was an independent predictor of recurrence, whereas post-SVR (aHR 0.84; 95% CI 0.57-1.24; p = 0.37) was not.

conclusionsAchieving SVR before or after LR decreased the mortality risk and achieving SVR before LR decreased the recurrence risk of patients with HCV-related HCC undergoing LR.

Indexed as

Direct-acting antiviralHepatitis C virusHepatocellular carcinomaInterferonOverall survivalRecurrence-free survivalSustained virological response

Identifiers

PMID42126785

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.