Evidence map›Paper›PMID 42126763›Full record

ArticleBioresources and bioprocessing2026

Proximity-enhanced co-immobilized enzyme cascade for efficient bioconversion of nicotine to 3-succinoylpyridine.

Yelong Wang, Jiandong Zhang, Hongjing Yang, Jinbin Wei, Kai Song, Shan Li, Laiwei Shen, Guangyu Yang, Mohamed Yassin Ali, Zhen Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioresources and bioprocessing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yelong WangSchool of Life Sciences and Biotechnology, Inner Mongolia Agricultural University, Hohhot, 010011, Inner Mongolia, China.
Jiandong ZhangTechnology Center, Gansu Tobacco Industrial Co., Ltd, Lanzhou, 730050, China.
Hongjing YangTechnology Center, Gansu Tobacco Industrial Co., Ltd, Lanzhou, 730050, China.
Jinbin WeiTechnology Center, Gansu Tobacco Industrial Co., Ltd, Lanzhou, 730050, China.
Kai SongTechnology Center, Gansu Tobacco Industrial Co., Ltd, Lanzhou, 730050, China.
Shan LiTechnology Center, Gansu Tobacco Industrial Co., Ltd, Lanzhou, 730050, China.
Laiwei ShenState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Guangyu YangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Mohamed Yassin AliState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhen WangTechnology Center, Gansu Tobacco Industrial Co., Ltd, Lanzhou, 730050, China. 361514540@qq.com.
Yong ZhangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China. yzhang2011@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-1497-5979
Yuzhen WangSchool of Life Sciences and Biotechnology, Inner Mongolia Agricultural University, Hohhot, 010011, Inner Mongolia, China. wangyuzhen@imau.edu.cn.

Funding

General Program Fund of China Tobacco Industry Development Center ZYSYM-2024-03Ministry of Science and Technology of the People's Republic of China 2024YFE0199700the Science and Technology Project Special Fund of Gansu Province 22YF11GA292
6 · The paper itself

Abstract

Tobacco waste, rich in nicotine, is both an environmental burden and a potential feedstock for high-value chemicals. Here, we developed a proximity-enhanced co-immobilized multi-enzyme cascade that efficiently converts the nicotine into a pharmaceutical intermediate 3-succinoylpyridine (SP). The cascade system comprises the nicotine oxidoreductase NicA2 V321 (NicAm), pseudooxynicotine amine oxidase (Pnao), and 3-succinoylsemialdehyde-pyridine dehydrogenase (Sapd) for sequential nicotine conversion, coupled with an aldehyde-ketone reductase (AKR) module for in situ NADP

Indexed as

3-succinoylpyridineCascade reactionCo-immobilizationNADP+ regenerationSelf-assembly

Identifiers

PMID42126763
PMCPMC13172129

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.