Evidence map›Paper›PMID 42126760›Full record

ReviewPituitary2026

Recent progress in the understanding of psychological complications of acromegaly: toward a longitudinal clinical phenotype.

Gabriella Martino, Orlando Silvestro, Francesco Ferraù, Salvatore Cannavò

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pituitary, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gabriella MartinoDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Orlando SilvestroDepartment of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Francesco FerraùDepartment of Human Pathology G. Barresi, University of Messina, Messina, Italy. fferrau@unime.it.
Salvatore CannavòDepartment of Human Pathology G. Barresi, University of Messina, Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acromegaly is a chronic endocrine disorder where biochemical remission often fails to ensure psychological recovery. Drawing on cross‑sectional, longitudinal and registry evidence, this paper proposes a longitudinal clinical phenotype to reconcile divergence between hormonal control and patient‑reported outcomes. Psychological burden unfolds along a temporal gradient, where HR‑QoL captures persistent functional and somatic sequelae, emotional distress reflects adaptive strain during disease transitions, and psychiatric morbidity emerges from cumulative dysfunction. Treatment burden, chronic pain/arthropathy and subtle cognitive deficits are highlighted as mediators that sustain or worsen psychological outcomes. This framework supports routine longitudinal psychological assessment and integrated management of residual structural burden and psychosocial adaptation to improve lived recovery.

Indexed as

AcromegalyHumansPhenotypeQuality of LifeAcromegalyClinical psychologyGH-secreting pituitary tumoursHealth psychologyHealth-related quality of lifePsychopathology

Identifiers

PMID42126760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.