Evidence map›Paper›PMID 42126732›Full record

ArticleRadiological physics and technology2026

The effect of boosted injection of saline on contrast effect in angiography.

Takashi Iwasaki, Hajime Sakamoto, Masaki Kuwabara, Masashi Saito, Hiroyuki Kobayashi, Shuji Sato, Takashi Omino, Yosuke Kogure, Shinsuke Kyogoku, Michimasa Suzuki

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Article in Radiological physics and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Takashi IwasakiDepartment of Radiology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan. t-iwasaki@juntendo.ac.jp.ORCID http://orcid.org/0009-0008-8580-4660
Hajime SakamotoDepartment of Medical Radiology, Graduate School of Health Sciences, Juntendo University, Tokyo, Japan.
Masaki KuwabaraDepartment of Radiology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.
Masashi SaitoDepartment of Radiology, Juntendo University Hospital, Tokyo, Japan.
Hiroyuki KobayashiCustomer Success Team, Nemoto Kyorindo Co., Ltd, Osaka, Japan.
Shuji SatoDepartment of Radiology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.
Takashi OminoDepartment of Radiology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.
Yosuke KogureDepartment of Radiology, Juntendo University Hospital, Tokyo, Japan.
Shinsuke KyogokuDepartment of Radiology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.
Michimasa SuzukiDepartment of Radiology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the effect of saline boost injections on angiographic contrast. Angiographic examinations were performed using a SIEMENS ArtisQ Celling (VD11E) system with syngo Workplace (VD20B) and a PRESS DUO elite autoinjector (Nemoto Kyorindo, Tokyo). Standard injection parameters, assuming non-selective angiography from the abdominal aortic bifurcation to the common femoral artery, were 5.0 mL/s for 2.0 s. Five boost conditions were assessed: injection speed of 5.0, 7.0, and 10.0 mL/s with total volumes of 5.0, 10.0, and 15.0 mL (1.0-3.0× standard), and 7.0 and 10.0 mL volumes corresponding to the amount delivered within 1.0 s. Time-enhancement curves (TECs) were generated from identical regions of interest placed in the proximal, middle, and distal portions of a vascular phantom to measure maximum signal intensity and enhancement duration. Additional quantitative analysis was performed using iFlow color-coded maps. Changes in the saline-flush boost volume resulted in minor differences compared with the baseline TECs. At a boost speed of 7.0 mL/s, maximum signal intensity increased by 7.2%, 8.1%, and 7.0% in the proximal, middle, and distal segments. At 10.0 mL/s, increases were 11.5%, 11.3%, and 11.1%, respectively. On iFlow analysis, the reference time-to-peak significantly shortened at 10.0 mL/s-3.49, 4.01, and 4.17 s-compared with 3.68, 4.22, and 4.26 s at baseline (p < 0.01). Boosting double-speed saline injection improved the efficiency of contrast agent delivery to distal regions. Further improvements in injection efficiency may reduce the required amount of contrast agent and the number of frames.

Indexed as

AngiographyContrast MediaSaline SolutionSodium ChlorideHumansInjectionsPhantoms, ImagingContrast MediaSaline SolutionSodium ChlorideAngiographyBoost double-speed injectionBoost injection volumeContrast agentiFlow color-coded maps

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.