ArticleActa parasitologica2026
Nitazoxanide Exhibits Schistosomicidal Activity Against Schistosomula and Adult Schistosoma mansoni and Influences Praziquantel-Associated Outcomes.
Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Schistosomiasis remains as a parasitic disease with major morbidity, ongoing transmission, and economic burden, particularly in tropical regions. Praziquantel is the first-line treatment but has limited efficacy against juvenile stages of the parasite. In this context, this study assessed the repurposing potential of anthelmintics against Schistosoma mansoni, focusing on the schistosomicidal activity of nitazoxanide (NTZ), levamisole (LVZ), and thiabendazole (TBZ). In vitro, NTZ exhibited a significant schistosomicidal activity, emerging as a repurposing candidate. In contrast, LVZ and TBZ showed no significant schistosomicidal activity. NTZ was active from 40 µg/mL, affecting schistosomula and adult worms in a dose-dependent manner. Ultrastructural analysis revealed wrinkling of the oral and ventral suckers and tegumental alterations in male worms, including shortening of ridges near the tubercles and the presence of multiple small protrusions. In vivo, NTZ showed partial efficacy, with 57.14% reduction in adult worm recovery, whereas PZQ achieved complete elimination. Infected animals presented a mean of 541.86 ± 273.13 viable eggs/cm
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