ArticleCerebellum (London, England)2026
Posterior Fossa Malformations in a Cohort of 116 Fetuses: A Retrospective Analysis of Imaging Characteristics, Postnatal Imaging Concordance, Pregnancy Outcomes and Yield of Genetic Testing.
Article in Cerebellum (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The posterior fossa is a critical anatomical region housing the cerebellum and brainstem. Posterior fossa malformations are a heterogeneous group of conditions challenging to diagnose and prognosticate prenatally. Fetal magnetic resonance imaging (MRI) plays an important role in their assessment. This retrospective study examined the clinical and radiological data from 115 maternal-fetal dyads (116 fetuses) with posterior fossa malformations on fetal MRI, assessed concordance with postnatal imaging, and investigated MRI features associated with adverse outcomes. Fetal posterior fossa malformations were heterogenous: 66% (76/116) were structural and 34% (40/116) involved only CSF-containing lesions. Cerebellar hypoplasia was the most frequent posterior fossa malformation, observed in 33% (38/116). 78% (91/116) of posterior fossa malformations were "complex" (with additional central nervous system and/or extraneural anomalies). Concordance between fetal MRI and postnatal imaging was 51% (27/53), which improved to 69% (20/29) when CSF-containing lesions were excluded. Among terminated pregnancies who underwent autopsy, the fetal MRI diagnosis was confirmed in 75% (12/16). Chiari-II malformations, pontocerebellar hypoplasia and cerebellar asymmetry were consistently confirmed on postnatal imaging. Four fetuses with cerebellar hypoplasia had normal postnatal imaging. Structural and "complex" posterior fossa malformations were more likely to have poor pregnancy outcomes (i.e., termination, fetal demise, or neonatal death) than CSF-only and isolated anomalies. Genetic testing was positive in 24% (19/80) of tested cases, and 16% (19/116) of the overall cohort. Fetal MRI has an important role in the accurate diagnosis and management of posterior fossa malformations, particularly for structural anomalies which are associated with poor pregnancy outcomes.
Indexed as
Identifiers
42126681What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.