ReviewMolecular biology reports2026
Autologous guided bone regeneration: a comprehensive narrative review.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- From passive fillers to active implants: A 3D-printed trilayer piezoelectric scaffold recapitulating native bone hierarchy.Bioactive materials · 2027Article
- Human Amniotic Epithelial Stem Cells and Osteoblast Cells Behavior on Collagen Membranes for Bone Guided Regeneration.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Bone defect is a prevalent and complex challenge in orthopedics and oral-maxillofacial surgery, severely compromising skeletal integrity and functional recovery. Autologous Guided Bone Regeneration (GBR) has emerged as a highly effective therapeutic strategy, demonstrating remarkable efficacy in treating long bone fractures, nonunions, post-tumor resection bone defects, and alveolar bone augmentation for dental implant procedures. This narrative review comprehensively synthesizes the latest research progress, core mechanisms, technical innovations, existing challenges, and future prospects of Autologous GBR through an extensive analysis of domestic and international literature. Its core mechanism relies on selective cell occlusion theory: barrier membranes construct a bone regeneration microenvironment, blocking non-osteoblastic invasion while promoting osteoblast migration and differentiation. Autologous components play key roles: autologous bone (gold standard for grafting) has osteogenic activity, osteoinductivity and osteoconductivity; autologous bone marrow provides mesenchymal stem cells (MSCs) for osteoblast differentiation and microenvironment regulation; autologous growth factors (e.g., Bone Morphogenetic Proteins [BMP], Transforming Growth Factor-β [TGF-β]) regulate bone regeneration via cell signaling pathways. Technical advances include site-specific autologous bone harvesting (ilium, mandible, etc.) and optimized barrier membranes (absorbable Poly Lactic-co-Glycolic Acid [PLGA]/collagen, non-absorbable expanded Polytetrafluoroethylene [ePTFE]). Cell-molecular studies (MSCs differentiation, Wnt pathway) offer theoretical basis. Challenges include surgical infection, potential immune rejection and poor osseointegration. Prospects involve 3D-printed scaffolds, gene therapy-tissue engineering combination, and application in complex diseases like osteogenesis imperfecta. This review provides references for researchers and clinicians.
Indexed as
Identifiers
42126655What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.