Evidence map›Paper›PMID 42126588›Full record

ReviewMedical molecular morphology2026

APC in the nervous system.

Takao Senda, Nami O Yamada, Takanori Onouchi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical molecular morphology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Takao SendaDepartment of Food and Nutrition Management, Faculty of Human Health, Sonoda University, 7-29-1 Minamitsukaguchi-Cho Amagasaki, Hyogo, 661-8520, Japan. tsenda@sonoda-u.ac.jp.ORCID http://orcid.org/0009-0000-6860-8491
Nami O YamadaDepartment of Anatomy, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Takanori OnouchiDepartment of Medical Technology, Faculty of Medical Sciences, Shubun University, 6 Nikko-Cho Ichinomiya, Aichi, 491-0938, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The APC (adenomatous polyposis coli) gene, which was first discovered as a colorectal cancer suppressor gene, is highly expressed in the nervous system. The Apc gene/Apc protein is deeply involved in brain development and morphogenesis. In the postnatal brain, Apc/Apc is involved in synaptic transmission, axon growth, and intracellular transport. Apc/Apc expressed in glial cells is involved in glial cell differentiation and neural circuit formation through glial cell functions. Reports from disease model animals and familial adenomatous polyposis (FAP) patients suggest that APC may be involved in the onset of autism, cognitive impairment, and schizophrenia.

Indexed as

Adenomatous Polyposis Coli ProteinNervous SystemAdenomatous Polyposis ColiAnimalsBrainHumansNeurodevelopmentNeurogliaSchizophreniaSynaptic TransmissionAdenomatous Polyposis Coli ProteinAdenomatous polyposis coli (APC)Autism spectrum disorderAxon elongationBrain developmentCognitive impairmentMicrotubulesNeuron immigrationPSD-95SchizophreniaSynaptic transmission

Identifiers

PMID42126588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.