Evidence map›Paper›PMID 42126566›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Astrocyte reactivity across the AD continuum measured by [

Yingying Wu, Kotaro Hiraoka, Berihu Mesfin, Asuka Kikuchi, Shoichi Watanuki, Shunji Mugikura, Naoki Tomita, Aiko Ishiki, Katsutoshi Furukawa, Yoshihito Funaki and 14 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yingying WuResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Kotaro HiraokaResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Berihu MesfinResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Asuka KikuchiResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Shoichi WatanukiResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Shunji MugikuraTohoku University Hospital, Tohoku University, Sendai, Japan.
Naoki TomitaTohoku University Hospital, Tohoku University, Sendai, Japan.
Aiko IshikiTohoku University Hospital, Tohoku University, Sendai, Japan.
Katsutoshi FurukawaTohoku University Hospital, Tohoku University, Sendai, Japan.
Yoshihito FunakiResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Jun ToyoharaTokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Yasuyuki KimuraNational Center for Geriatrics and Gerontology, Obu, Japan.
Ryuichi HaradaResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Shozo FurumotoResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Akio KikuchiTohoku University Hospital, Tohoku University, Sendai, Japan.
Hiroshi WatabeResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Ryota KobayashiYamagata University Hospital, Yamagata, Japan.
Takashi NihashiNational Center for Geriatrics and Gerontology, Obu, Japan.
Takashi KatoNational Center for Geriatrics and Gerontology, Obu, Japan.
Kenji IshiiTokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Shinobu KawakatsuAizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.
Nobuyuki OkamuraResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.
Manabu TashiroResearch Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. manabu.tashiro.a2@tohoku.ac.jp.ORCID 0000-0002-8860-6917
SMBTSD study project group*

Funding

Japan Society for the Promotion of Science (JSPS) 16H06278Japan Society for the Promotion of Science (JSPS) 21H02862the Japan Agency for Research and Development (AMED) 21dk0207058h0001
6 · The paper itself

Abstract

purposeAstrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer's disease (AD) brain tissue; however, their spatiotemporal dynamics in vivo remain poorly understood. This multicenter study aimed to investigate the progression of astrocyte reactivity across the AD continuum, including healthy controls (HC), mild cognitive impairment (MCI), and AD, using the novel monoamine oxidase B (MAO-B)-specific PET tracer [

methodsA total of 91 participants (35 HC, 44 MCI, 12 AD) underwent [

results[

conclusionThis study demonstrates that [ CLINICAL

trial registrationJapan Registry of Clinical Trials (jRCT) jRCTs031210602, registered Feb. 07, 2022. URL FOR THE TRIAL REGISTRY: https://jrct.mhlw.go.jp/en-latest-detail/jRCTs031210602 .

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAstrocytesPositron-Emission TomographyAgedCognitive DysfunctionFemaleFluorine RadioisotopesHumansMaleMonoamine OxidaseAmyloid beta-PeptidesFluorine RadioisotopesMonoamine Oxidase[18F]SMBT-1Alzheimer's diseaseAmyloid-β (Aβ)Mild cognitive impairment (MCI)Monoamine oxidase B (MAO-B)Reactive astrogliosis

Identifiers

PMID42126566
PMCPMC13421302

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.