ArticleEuropean radiology experimental2026
Intravoxel incoherent motion MRI for early detection and assessment of renal injury after cardiac arrest and resuscitation in a rat model.
Article in European radiology experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the utility of intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) for early detection of renal injury 24 h after cardiac arrest and cardiopulmonary resuscitation. MATERIALS AND
methodsTwenty-four male Sprague-Dawley rats were randomized into cardiac arrest (n = 15) and sham-operated (n = 9) groups. Five cardiac arrest rats died during the procedure, resulting in 10 cardiac arrest and 9 sham rats for analysis. IVIM-MRI and renal parameters were assessed 24 h after cardiac arrest and cardiopulmonary resuscitation. Diffusion-related parameters, including apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), and exponential ADC (eADC), were obtained. The primary imaging endpoint was defined as D. Following completion of MRI, renal function, histopathology, and expression of apoptosis markers (Bcl-2, Caspase-3), water channel protein aquaporin-3, and tight junction proteins (zonula occludens-1, occludin) were subsequently evaluated.
resultsDespite preserved conventional renal function, IVIM MRI detected early renal alterations 24 h after cardiac arrest. Compared with the sham group, eADC, D, ADC, D*, and f values were all significantly reduced. Histopathological analysis revealed pronounced tubular epithelial injury, increased apoptosis (Bcl-2, p < 0.001; Caspase-3, p = 0.010), and reduced expression of aquaporin-3 (p = 0.039), zonula occludens-1 (p < 0.001), and occludin (p < 0.001).
conclusionIVIM MRI enables early, noninvasive detection of renal injury 24 h after cardiac arrest and CPR, reflecting tubular injury, tight junction disruption, and perfusion deficits, potentially facilitating timely intervention and improving prognosis. RELEVANCE STATEMENT: This approach may facilitate individualized therapy and improve post-cardiac arrest syndrome outcome. KEY POINTS: The long-term outcomes of cardiac arrest remain poor due to post-cardiac arrest syndrome. IVIM MRI enables early, noninvasive detection of renal injury after cardiac arrest and cardiopulmonary resuscitation. This approach may facilitate individualized therapy and improve post-cardiac arrest syndrome.
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