ArticleJournal of natural medicines2026
New pentandralactams from Vietnamese Ceiba pentandra (L.) Gaertn. and their anti-inflammatory activity via NO production inhibition.
Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A phytochemical study on the 70% ethanol extract of the stem bark of Vietnamese Ceiba pentandra (L.) Gaertn led to the isolation of the three new sesquiterpene alkaloids pentandralactams A (1), B (2), and C (3), along with the six known compounds thespesilactam (4), isohemigossylic acid lactone-2-methyl ether (5), alanense H (6), hibiscolactone A (7), 11-hydroxy-2-O-methylhibiscolactone A (8), and vavain 3'-O-β-D-glucoside (9). Their structures were elucidated through extensive spectroscopic analyses, including HR-ESI-MS, and 1D and 2D NMR. All isolates were tested for their ability to inhibit NO production in LPS-induced RAW 264.7 cells. The sesquiterpene alkaloids pentandralactams A-C (1 - 3) exhibited potent NO inhibition with IC
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