Evidence map›Paper›PMID 42126466›Full record

SynthesisJournal of robotic surgery2026

NeuroSAFE-guided robot-assisted radical prostatectomy versus standard RARP: systematic review and meta-analysis of comparative studies.

Caio Vinicius Suartz, José Pedro Cassemiro Micheleto, Bianca Espadilha Condotta, Leonam Bringhenti Schumacher, Ketlyn Assunção Galhardo, Maria Fernanda Dias Azevedo, Pedro Henrique Souza Brito, Daher Chade, José Maurício Mota, Maurício Cordeiro Dener and 13 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of robotic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Caio Vinicius SuartzDepartment of Urology, Northern Ontario School of Medicine University, Thunder Bay, ON, Canada. caio.v_suartz@hotmail.com.
José Pedro Cassemiro MicheletoDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Bianca Espadilha CondottaDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Leonam Bringhenti SchumacherDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Ketlyn Assunção GalhardoDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Maria Fernanda Dias AzevedoDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Pedro Henrique Souza BritoDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Daher ChadeDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
José Maurício MotaGenitourinary Medical Oncology Service, São Paulo State Cancer Institute, University of São Paulo, São Paulo, Brazil.
Maurício Cordeiro DenerDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Thalita Bento TalizinDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Walid SharourDepartment of Urology, Northern Ontario School of Medicine University, Thunder Bay, ON, Canada.
Walid ShabanaDepartment of Urology, Northern Ontario School of Medicine University, Thunder Bay, ON, Canada.
Roberto Iglesias LopesDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Marian WettsteinDepartment of Urology, Northern Ontario School of Medicine University, Thunder Bay, ON, Canada.
Mohamed ElkoushyDepartment of Urology, Northern Ontario School of Medicine University, Thunder Bay, ON, Canada.
William Carlos NahasDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.
Bárbara Vieira Lima Aguiar MelãoDepartamento de Oncologia, Hospital Adventista de Manaus, Manaus, Amazonas, Brasil.
Murilo de Almeida LuzDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Leonardo Oliveira ReisUroScience, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Jose de Bessa JuniorDepartment of Surgery, State University of Feira de Santana, Feira de Santana, Brazil.
Roni De Carvalho FernandesSchool of Medical Sciences, Santa Casa de São Paulo, São Paulo, Brazil.
Leopoldo Alves Ribeiro FilhoDivision of Urology, Institute of Cancer of São Paulo, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer is the most common male malignancy, and although robotic-assisted radical prostatectomy (RARP) is widely used, urinary incontinence and erectile dysfunction remain significant issues. NeuroSAFE, an intraoperative frozen section technique aimed at optimizing nerve preservation without compromising cancer control, is increasingly used, but its overall impact on outcomes remains unclear.To systematically evaluate the effectiveness and safety of the NeuroSAFE technique during RARP, comparing functional recovery and oncologic outcomes with non-NeuroSAFE approaches.This systematic review and meta-analysis followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD420251032774). A comprehensive search of Embase, MEDLINE, and ClinicalTrials.gov (March, 2026) identified studies reporting oncologic and/or functional outcomes in men undergoing RARP with NeuroSAFE. Two reviewer teams independently conducted study selection, data extraction, and risk-of-bias assessment using ROBINS-I tool. Random-effects meta-analyses estimated pooled odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity was quantified with the I

Indexed as

Frozen SectionsProstatectomyProstatic NeoplasmsRobotic Surgical ProceduresErectile DysfunctionHumansMalePostoperative ComplicationsTreatment OutcomeUrinary IncontinenceMeta-analysisNeuroSAFEProstate cancerProstatectomyRobot-assisted radical prostatectomy

Identifiers

PMID42126466
PMCPMC13171698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.