ArticleJACC. Case reports2026
Rapid Onset of Iron Overload Cardiomyopathy in Cirrhosis.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Iron and Other Metal Ions in Human Health and Disease.MedComm · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron overload cardiomyopathy (IOC) is a rare cause of heart failure classically associated with hereditary or transfusion-related hemochromatosis. Although iron accumulation occurs in cirrhosis, the development and clinical course of IOC in this population remain poorly described. We report 2 patients with cirrhosis who developed IOC without hereditary hemochromatosis or transfusion-dependent anemia. Patient #1 was a 54-year-old man with alcohol-associated cirrhosis who developed severe cardiomyopathy (left ventricular ejection fraction 23%, 55% 1 year earlier). Patient #2 was a 56-year-old man with cryptogenic cirrhosis who presented with new cardiomyopathy (left ventricular ejection fraction 38%, 71% 9 months earlier). Both patients had elevated ferritin and transferrin saturation, along with reduced myocardial T2∗ relaxation time on cardiac magnetic resonance imaging, consistent with IOC. Both received iron chelation therapy; one patient died, and the other is awaiting combined heart-liver transplantation. These cases highlight IOC as an important consideration in patients with cirrhosis presenting with new cardiomyopathy.
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