ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026
Catalyst-Free Cyanation of Arenes by Acetonitrile in a Plasma-Liquid Microreactor.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A catalyst-free direct C-H cyanation of arenes was performed in continuous flow by treating aromatic substrates in acetonitrile with an argon plasma in a gas-liquid microreactor under ambient conditions. The reactivity of the different radicals generated through plasma activation of acetonitrile was probed using benzene as a model substrate, producing benzonitrile in a 25% yield. Mechanistic insights derived from kinetic modeling and isotopic labeling experiments enabled the proposal of a reaction pathway accounting for the formation of the main nitrile products. Expanding the substrate scope demonstrated consistent nitrile formation aligned with the mechanistic hypothesis. This catalyst-free direct C-H cyanation of arenes using an accessible and low-toxicity nitrile source highlights the promising role of plasma activation as an alternative tool for organic transformations.
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