Evidence map›Paper›PMID 42126255›Full record

ArticlemBio2026

Composition and role of the vacuolar transporter chaperone complex in polyphosphate synthesis and infectivity in

Mayara S Bertolini, Miguel A Chiurillo, Roberto Docampo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The roles and synthesis of inorganic polyphosphate inbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mayara S BertoliniDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Miguel A ChiurilloDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-5581-9027
Roberto DocampoDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-4229-8784

Funding

Polyphosphate and cardiac fibrosis by Trypanosoma cruziR21AI173402 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2023 to 2024
$415k
American Heart Association 24Post1196440NIAID NIH HHS R21 AI173402
6 · The paper itself

Abstract

Inorganic polyphosphate (polyP) is a linear polymer composed of three to several hundred orthophosphate units linked by high-energy phosphoanhydride bonds and is found in both prokaryotes and eukaryotes. In IMPORTANCE: Chagas disease affects millions of people across the Americas and remains a major unmet medical challenge. Here, we investigate the essentiality and molecular composition of the vacuolar transporter chaperone (VTC) complex in

Indexed as

Molecular ChaperonesPolyphosphatesProtozoan ProteinsTrypanosoma cruziAnimalsGene Knockout TechniquesHumansVacuolesMolecular ChaperonesPolyphosphatesProtozoan Proteinsinorganic polyphosphateinositol pyrophosphateTrypanosoma cruzivacuolar transporter chaperone

Identifiers

PMID42126255
PMCPMC13251457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.